The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study
文献类型：期刊论文
| 作者 | Zhang, Zhang-Jin3,4; Tan, Qing-Rong3; Tong, Yao4; Li, Qiang2; Kang, Wan-Hu2; Zhen, Xue-Chu5; Post, Robert M.1 |
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2008-07 |
| 卷号 | 109期号:1-2页码:91-97 |
| 关键词 | carbamazepine unipolar depression major depressive disorder clinical trial |
| ISSN号 | 0165-0327 |
| DOI | 10.1016/j.jad.2007.11.004 |
| 文献子类 | Article |
| 英文摘要 | Our previous studies have shown the effectiveness of carbamazepine (CBZ) in the treatment of bipolar depression. This double-blind, randomized, placebo-controlled study was designed to further evaluate the efficacy of CBZ in unipolar depressed subjects who never received antidepressant and other psychotherapeutic treatment. A total of 89 patients who had at least two major depressive episodes, but never experienced mania or hypomania, were randomly assigned to treatment with immediate-release CBZ 300-800 mg/daily (n = 51) or placebo (n = 38) for 12 weeks. The primary efficacy was measured using the Hamilton Rating Scale for Depression (HAMD), Montgomery-Asberg Depression Rating Scale (MADRS), and Clinical Global Impression-Severity (CGI-S). The mean final CBZ dose of CBZ-treated patients was 461.6 mg/day. CBZ treatment yielded significantly greater improvements on the three efficacy measures at week 8 through endpoint compared to placebo. Patients assigned to CBZ treatment also had a significantly higher clinical response rate than placebo (74% vs. 42%, p<0.001), as defined for >= 50% reduction in HAMD score. Based on the results of our present and previous studies, we suggest that CBZ might be considered an alternative in the management of certain conditions in major depressive disorder. (C) 2007 Elsevier B.V All rights reserved. |
| WOS关键词 | ANTIEPILEPTIC DRUGS ; BIPOLAR DEPRESSION ; MOOD DISORDERS ; MAJOR DEPRESSION ; HERBAL MEDICINE ; ANTIDEPRESSANTS ; SWITCH ; VENLAFAXINE ; PREVALENCE ; MEDICATION |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000256987300009 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272878]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhang, Zhang-Jin |
| 作者单位 | 1.Penn State Sch Med, Hershey, PA USA 2.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Psychiat, Xian 710061, Shannxi, Peoples R China; 3.Fourth Mil Med Univ, Dept Psychiat, Xijing Hosp, Xian 710032, Shannxi, Peoples R China; 4.Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Zhang-Jin,Tan, Qing-Rong,Tong, Yao,et al. The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study[J]. JOURNAL OF AFFECTIVE DISORDERS,2008,109(1-2):91-97. |
| APA | Zhang, Zhang-Jin.,Tan, Qing-Rong.,Tong, Yao.,Li, Qiang.,Kang, Wan-Hu.,...&Post, Robert M..(2008).The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study.JOURNAL OF AFFECTIVE DISORDERS,109(1-2),91-97. |
| MLA | Zhang, Zhang-Jin,et al."The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study".JOURNAL OF AFFECTIVE DISORDERS 109.1-2(2008):91-97. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。