Anti-Helicobacter pylori and thrombin inhibitory components from Chinese Dragon's blood, Dracaena cochinchinensis
文献类型：期刊论文
| 作者 | Zhu, Yingdong; Zhang, Ping; Yu, Haiping; Li, Ha; Wang, Ming-Wei ; Zhao, Weimin
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2007-10 |
| 卷号 | 70期号:10页码:1570-1577 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np070260v |
| 文献子类 | Article |
| 英文摘要 | Chemical studies on the constituents of Dracaena cochinchinensis led to the discovery of eight new flavonoid derivatives (1-8) along with 14 known compounds (9-22). The identification and structural elucidation of these isolates were based on spectral analyses. All isolates were tested for antibacterial activities against Helicobacter pylori (ATCC43504) and thrombin inhibitory effects. As a result, new flavonoid derivatives 6 and 7 and (2S)-4',7-dihydroxy-8-methylflavan (11) were found to be most efficacious against H. pylori (ATCC43504) with MIC values of 29.5, 29.5, and 31.3 mu M, respectively, and the seven new flavonoid derivatives (1-7) and one known biflavonoid (9) were observed to exhibit moderate thrombin inhibitory activity. |
| WOS关键词 | PEPTIC-ULCER DISEASE ; CAMPYLOBACTER-PYLORI ; STEROIDAL SAPONINS ; PHENOLIC-COMPOUNDS ; CONSTITUENTS ; CINNABARI ; INFECTION ; PLANTS ; DRACO ; HOMOISOFLAVONOIDS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000250555700005 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273139]  |
| 专题 | 国家新药筛选中心 天然药物化学研究室 |
| 通讯作者 | Zhao, Weimin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Natl Ctr Durg Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Yingdong,Zhang, Ping,Yu, Haiping,et al. Anti-Helicobacter pylori and thrombin inhibitory components from Chinese Dragon's blood, Dracaena cochinchinensis[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(10):1570-1577. |
| APA | Zhu, Yingdong,Zhang, Ping,Yu, Haiping,Li, Ha,Wang, Ming-Wei,&Zhao, Weimin.(2007).Anti-Helicobacter pylori and thrombin inhibitory components from Chinese Dragon's blood, Dracaena cochinchinensis.JOURNAL OF NATURAL PRODUCTS,70(10),1570-1577. |
| MLA | Zhu, Yingdong,et al."Anti-Helicobacter pylori and thrombin inhibitory components from Chinese Dragon's blood, Dracaena cochinchinensis".JOURNAL OF NATURAL PRODUCTS 70.10(2007):1570-1577. |
入库方式： OAI收割
来源：上海药物研究所
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