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Procyanidin dimer B2 [epicatechin-(4 beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells

文献类型：期刊论文

作者Zhang, WY; Liu, HQ; Xie, KQ; Yin, LL; Li, Y; Kwik-Uribe, CL; Zhu, XZ
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2006-06-23
卷号345期号:1页码:508-515
关键词cocoa procyanidin cyclooxygenase-2 (COX-2) mitogen-activated protein kinase (MAPK) nuclear factor kappa B (NF-kappa B)
ISSN号0006-291X
DOI10.1016/j.bbrc.2006.04.085
文献子类Article
英文摘要The anti-inflammatory activity of the predominant procyanidin dimer in cocoa, dimer B2, was investigated in this study. Pretreatment of the procyanidin dimer B2 reduced COX-2 expression induced by the endotoxin lipopolysaccharide (LPS) in differentiated human monocytic cells (THP-1) in culture. To further elucidate the underlying mechanism of COX-2 inhibition by procyanidin, we examined their effects on the activation of extracellular signal-regulated protein kinase (ERK), Jun-terminal kinase (INK), and p38 mitogen-activated protein kinase (MAPK), which are upstream enzymes known to regulate COX-2 expression in many cell types. Pretreatment with procyanidin dimer B2 decreased the activation of ERK, JNK, and p38 MAPK. In addition, procyanidin dimer B2 suppressed the NF-kappa B activation through stabilization of I kappa B proteins, suggesting that these signal-transducing enzymes could be potential targets for procyanidin dimer B2. By affecting the expression rather than the activity of COX-2, these in vitro data reported herein give further evidence on the anti-inflammatory protection by procyanidins. (c) 2006 Elsevier Inc. All rights reserved.
WOS关键词ACTIVATED PROTEIN-KINASE ; NF-KAPPA-B ; MOUSE SKIN ; CYCLO-OXYGENASE-2 EXPRESSION ; COCOA PROCYANIDINS ; SIGNALING PATHWAYS ; TEA POLYPHENOLS ; LIPOPOLYSACCHARIDE ; INHIBITION ; MACROPHAGES
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000237877700069
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/273561]  
专题药理学第二研究室
通讯作者Zhu, XZ
作者单位Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, WY,Liu, HQ,Xie, KQ,et al. Procyanidin dimer B2 [epicatechin-(4 beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,345(1):508-515.
APA Zhang, WY.,Liu, HQ.,Xie, KQ.,Yin, LL.,Li, Y.,...&Zhu, XZ.(2006).Procyanidin dimer B2 [epicatechin-(4 beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,345(1),508-515.
MLA Zhang, WY,et al."Procyanidin dimer B2 [epicatechin-(4 beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345.1(2006):508-515.

入库方式： OAI收割

来源：上海药物研究所

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