Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats
文献类型：期刊论文
| 作者 | Liu, Jing; Jin, Dao-Zhong; Xiao, Liang; Zhu, Xing-Zu |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2006-05-17 |
| 卷号 | 1089页码:162-170 |
| 关键词 | astrocyte chronic cerebral hypoperfusion microglia nuclear factor-kappa B paeoniflorin spatial learning |
| ISSN号 | 0006-8993 |
| DOI | 10.1016/j.brainres.2006.02.115 |
| 文献子类 | Article |
| 英文摘要 | Chronic cerebral hypoperfusion, a mild ischemic condition, is associated with the cognitive deficits of AD. Paeoniflorin (PF), a major constituent of peony root, was proved to be neuroprotective in middle cerebral artery occlusion model. In this study, we investigated whether PF could attenuate chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rat. Seven weeks after permanent bilateral occlusion of the common carotid arteries, the rats were tested in the Morris water maze. Subsequently, the animals were sacrificed and neurons, astrocytes and microglias were labeled with immunocytochemistry in hippocampus. PF at the dose of 2.5 mg/kg ameliorated cerebral hypoperfusion-related learning dysfunction and prevented CA1 neuron damage. Chronic cerebral hypoperfusion increased the immunoreactivity of astrocytes and microglias in hippocampus. The increase was prevented by PF at the dose of 2.5 mg/kg. Cerebral hypoperfusion also increased expression of nuclear factor-kappa B (NF-kappa B), mostly in astrocytes, but not in neurons. With the treatment of PF (2.5 mg/kg), NF-kappa B immunostaining was diminished in hippocampus. Our results demonstrated that PF could attenuate cognitive deficit and brain damage induced by chronic cerebral hypoperfusion. and that suppression of neuroinflammatory reaction in brain might be involved in PF-induced neuroprotection. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS关键词 | NF-KAPPA-B ; BIOLOGICALLY-ACTIVE PRINCIPLES ; ANTI-ALLERGIC PRINCIPLES ; ADENOSINE A(1) RECEPTOR ; ALZHEIMERS-DISEASE ; BLOOD-FLOW ; COGNITIVE IMPAIRMENT ; MAJOR CONSTITUENT ; SHOSEIRYU-TO ; CRUDE DRUGS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000238471300016 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273593]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, Xing-Zu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jing,Jin, Dao-Zhong,Xiao, Liang,et al. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats[J]. BRAIN RESEARCH,2006,1089:162-170. |
| APA | Liu, Jing,Jin, Dao-Zhong,Xiao, Liang,&Zhu, Xing-Zu.(2006).Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats.BRAIN RESEARCH,1089,162-170. |
| MLA | Liu, Jing,et al."Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats".BRAIN RESEARCH 1089(2006):162-170. |
入库方式： OAI收割
来源：上海药物研究所
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