Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells
文献类型：期刊论文
| 作者 | Gao, YG; Song, AX; Shi, YH ; Chang, YG; Liu, SX; Yu, YZ; Cao, XT; Lin, DH; Hu, HY
|
| 刊名 | PROTEIN SCIENCE
 |
| 出版日期 | 2005-08 |
| 卷号 | 14期号:8页码:2044-2050 |
| 关键词 | solution structure dynamics ubiquitin-like domain DC-UbP NMR |
| ISSN号 | 0961-8368 |
| DOI | 10.1110/ps.051455505 |
| 文献子类 | Article |
| 英文摘要 | The previously identified dendritic cell-derived ubiquitin-like protein (DC-UbP) was implicated in cellular differentiation and apoptosis. Sequence alignment suggested that it contains a ubiquitin-like (UbL) domain in the C terminus. Here, we present the solution NMR structure and backbone dynamics of the UbL domain of DC-UbP. The overall structure of the domain is very similar to that of Ub despite low similarity (< 30%) in amino-acid sequence. One distinct feature of the domain structure is its highly positively charged surface that is different from the corresponding surfaces of the well-known UbL modifiers, Ub, NEDD8, and SUMO-1. The key amino-acid residues responsible for guiding polyubiquitinated proteins to proteasome degradation in Ub are not conserved in the UbL domain. This implies that the UbL domain of DC-UbP may have its own specific interaction partners with other yet unknown cellular functions related to the Ub pathway. |
| WOS关键词 | N-15 NMR RELAXATION ; CONJUGATION SYSTEM ; CHEMICAL-SHIFT ; PROTEIN ; FAMILY ; SUMO ; DESTRUCTION ; PROTEASOME ; RESTRAINTS ; AUTOPHAGY |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000230872900011 |
| 出版者 | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273829]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Hu, HY |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 3.Secondary Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China 4.Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, YG,Song, AX,Shi, YH,et al. Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells[J]. PROTEIN SCIENCE,2005,14(8):2044-2050. |
| APA | Gao, YG.,Song, AX.,Shi, YH.,Chang, YG.,Liu, SX.,...&Hu, HY.(2005).Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells.PROTEIN SCIENCE,14(8),2044-2050. |
| MLA | Gao, YG,et al."Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells".PROTEIN SCIENCE 14.8(2005):2044-2050. |
入库方式： OAI收割
来源：上海药物研究所
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