The involvement of central cholinergic system in (+)-matrine-induced antinociception in mice
文献类型：期刊论文
| 作者 | Yin, LL; Zhu, XZ |
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2005-03 |
| 卷号 | 80期号:3页码:419-425 |
| 关键词 | (+)-matrine antinociception central cholinergic system atropine opioid receptors binding assay |
| ISSN号 | 0091-3057 |
| DOI | 10.1016/j.pbb.2004.12.008 |
| 文献子类 | Article |
| 英文摘要 | The antinociceptive effect of (+)-matrine was examined in mice by writhing, tail-pressure and hot-plate tests. (+)-Matrine (5, 10 and 20 mg/kg s.c.) produced antinociception in a dose-dependent manner. In hot-plate test, the antinociception produced by (+)-matrine (10 mg/kg s.c.) was attenuated by muscarinic receptor antagonists atropine (5 mg/kg i.p.) and pirenzepine (0.1 mu g/mouse i.c.v.) and acetylcholine depletor hemicholinium-3 (HC-3) (1 mu g/mouse i.c.v.), but not by opioid receptor antagonist naloxone (2 mg/kg i.p.), dopamine D-2 receptor agonist (-)-quinpirole (0.1 mg/kg i.p.) or catecholamine depletor reserpine (2.5 mg/kg i.p.). Radioligand binding assay demonstrated that (+)-matrine had no affinity for mu-, kappa- or delta-opioid receptors in a wide concentration range (1 x 10(-11)-1 x 10(-3) M). The results suggest that (+)matrine exerts its antinociceptive effect through multiple mechanism(s) such as increasing cholinergic activation in the CNS rather than acting on opioid receptors directly. (c) 2004 Elsevier Inc. All rights reserved. |
| WOS关键词 | MATRINE-TYPE ALKALOIDS ; MECHANISM ; ANALGESIA |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000227732200008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273903]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, LL,Zhu, XZ. The involvement of central cholinergic system in (+)-matrine-induced antinociception in mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2005,80(3):419-425. |
| APA | Yin, LL,&Zhu, XZ.(2005).The involvement of central cholinergic system in (+)-matrine-induced antinociception in mice.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,80(3),419-425. |
| MLA | Yin, LL,et al."The involvement of central cholinergic system in (+)-matrine-induced antinociception in mice".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 80.3(2005):419-425. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。