Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis
文献类型：期刊论文
| 作者 | Wang, LZ; Sun, WC; Zhu, XZ |
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2005-01-31 |
| 卷号 | 508期号:1-3页码:57-68 |
| 关键词 | Parkinson's disease dopamine ethyl pyruvate oxidative stress nuclear transcription factor kappa B p53 |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2004.12.020 |
| 文献子类 | Article |
| 英文摘要 | Pyruvate acid can protect cells against oxidative damage. However, its instability limits its usefulness as a therapeutic agent. In this study, we examined the effect of ethyl pyruvate, an aliphatic ester derived from pyruvate acid, on dopamine-induced cytotoxicity in rat pheochromocytoma PC12 cells. The results demonstrated that dopamine induced apoptosis in PC12 cells accompanied with increases of intercellular reactive oxygen species, nuclear translocation of nuclear transcription factor kappa B (NF-kappaB) and expression of p53 and decrease of mitochondrial transmembrane potential. Ethyl pyruvate markedly reduced the dopamine-induced production of reactive oxygen species, nuclear translocation of NF-kappaB, upregulation of p53, loss of mitochondrial transmembrane potential and apoptosis in PC12 cells. The results suggested that ethyl pyruvate might protect PC12 cells against dopamine by suppressing intercellular oxidative stress and modulating key signal pathways of apoptosis, and that ethyl pyruvate might be used as a potential therapeutic agent for Parkinson's disease. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS关键词 | NF-KAPPA-B ; CENTRAL-NERVOUS-SYSTEM ; ROTENONE-INDUCED APOPTOSIS ; BCL-2 FAMILY PROTEINS ; TUMOR-SUPPRESSOR P53 ; PARKINSONS-DISEASE ; BRAIN MITOCHONDRIA ; HYDROGEN-PEROXIDE ; OXIDATIVE STRESS ; SH-SY5Y CELLS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000226894000007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273937]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, LZ,Sun, WC,Zhu, XZ. Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2005,508(1-3):57-68. |
| APA | Wang, LZ,Sun, WC,&Zhu, XZ.(2005).Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis.EUROPEAN JOURNAL OF PHARMACOLOGY,508(1-3),57-68. |
| MLA | Wang, LZ,et al."Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis".EUROPEAN JOURNAL OF PHARMACOLOGY 508.1-3(2005):57-68. |
入库方式： OAI收割
来源：上海药物研究所
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