Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion
文献类型：期刊论文
| 作者 | Yu, WY; Guo, W; Feng, LY
|
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2004-11-05 |
| 卷号 | 577期号:1-2页码:87-92 |
| 关键词 | lipid raft Nogo66 Nogo66 receptor p75 signal transduction cholesterol depletion |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/j.febslet.2004.09.068 |
| 文献子类 | Article |
| 英文摘要 | NogoA, a myelin-associated component, inhibits neurite outgrowth. Nogo66, a portion of NogoA, binds to Nogo66 receptor (NgR) and induces the inhibitory signaling. LINGO-1 and p75 neurotrophin receptor (p75), the low-affinity nerve growth factor receptor, are also required for NogoA signaling. However, signaling mechanisms downstream to Nogo receptor remain poorly understood. Here, we observed that NgR and p75 were colocalized in low-density membrane raft fractions derived from forebrains and cerebella as well as from cerebellar granule cells. NgR interacted with p75 in lipid rafts. In addition, disruption of lipid rafts by beta-methylcyclodextrin, a cholesterol-binding reagent, reduced the Nogo66 signaling. Our results suggest an important role of lipid rafts in facilitating the interaction between NgRs and provide insight into mechanisms underlying the inhibition of neurite outgrowth by NogoA. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | MYELIN-ASSOCIATED GLYCOPROTEIN ; CELL-ADHESION MOLECULES ; NERVE GROWTH CONES ; NEURITE OUTGROWTH ; NOGO-66 RECEPTOR ; DEPENDENT RECRUITMENT ; AXONAL REGENERATION ; ANCHORED PROTEINS ; MEMBRANE DOMAINS ; P75 RECEPTOR |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000225128600015 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273994]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Feng, LY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Inst Neurosci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, WY,Guo, W,Feng, LY. Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion[J]. FEBS LETTERS,2004,577(1-2):87-92. |
| APA | Yu, WY,Guo, W,&Feng, LY.(2004).Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion.FEBS LETTERS,577(1-2),87-92. |
| MLA | Yu, WY,et al."Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion".FEBS LETTERS 577.1-2(2004):87-92. |
入库方式： OAI收割
来源：上海药物研究所
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