Homodimerization of human Mu-opioid receptor overexpressed in Sf9 insect cells
文献类型：期刊论文
| 作者 | Chen, LW; Can, G; Zhou, DH; Wei, Q; Xu, XJ; Chen, J ; Chi, ZQ
|
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2002-04 |
| 卷号 | 9期号:2页码:145-152 |
| 关键词 | G protein coupled receptors Mu opioid receptors Baculovirus Sf9 insect cells homodimerization |
| ISSN号 | 0929-8665 |
| DOI | 10.2174/0929866023408850 |
| 文献子类 | Article |
| 英文摘要 | In this study, we demonstrate that human mu-opioid receptors do form SDS-resistant homodimers and examine the ability of human mu-opioid receptors to dimerize and the role of agonists in the dimerization. Increasing concentrations and longer exposure of agonists reduce the levels of dimmer with a corresponding increase in the levels of monomer. This effect is achieved with both peptide and alkaloid opioid agonists and it is antagonist reversible. These results suggest that human mu-opioid receptors are present as receptor oligomers and interconversion between dimeric and monomeric forms may be important for biological activity. |
| WOS关键词 | BACULOVIRUS SYSTEM ; GABA(B) RECEPTOR ; OPIATE-RECEPTOR ; BINDING-SITE ; INTERNALIZATION ; OHMEFENTANYL ; DIMERIZATION ; AFFINITY ; DIMERS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000175150300007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274373]  |
| 专题 | 药理学第二研究室 院士及顾问专家 药物安全性评价中心 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, LW,Can, G,Zhou, DH,et al. Homodimerization of human Mu-opioid receptor overexpressed in Sf9 insect cells[J]. PROTEIN AND PEPTIDE LETTERS,2002,9(2):145-152. |
| APA | Chen, LW.,Can, G.,Zhou, DH.,Wei, Q.,Xu, XJ.,...&Chi, ZQ.(2002).Homodimerization of human Mu-opioid receptor overexpressed in Sf9 insect cells.PROTEIN AND PEPTIDE LETTERS,9(2),145-152. |
| MLA | Chen, LW,et al."Homodimerization of human Mu-opioid receptor overexpressed in Sf9 insect cells".PROTEIN AND PEPTIDE LETTERS 9.2(2002):145-152. |
入库方式： OAI收割
来源：上海药物研究所
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