Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity
文献类型：期刊论文
| 作者 | Bao, XF; Duan, JY; Fang, XY; Fang, JN |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2001-11-08 |
| 卷号 | 336期号:2页码:127-140 |
| 关键词 | Ganoderma lucidum (1 -> 3)-alpha-D-glucan chemical modification immunological activity |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/S0008-6215(01)00238-5 |
| 文献子类 | Article |
| 英文摘要 | A linear (1 --> 3)-alpha -D-glucan was isolated from the spores of Ganoderma lucidum (Fr.) Karst. Six different functionalized derivatives of the (1 --> 3)-alpha -D-glucan-aminopropylated, hydroxyethylated, sulfated, carboxymethylated, carboxymethylated and sulfated, and benzylamidated-carboxymethylated-with varying degrees of substitution were synthesized. The structural features and physicochemical properties of all derivatives were investigated by means of chemical and spectral analyses, and their effects on lymphocyte proliferation and antibody production were tested in vitro and in vivo. In general, the structural and physicochemical properties, and lymphocyte proliferation activity of all samples varied with the functionalized groups and the degree of substitution. The results of immunological assays indicated that some modified derivatives had potent stimulating effects on lymphocyte proliferation and antibody production and the introduction of carboxymethyl group with low degree of substitution (DS < 0.28) was the best choice on the improvement of the immunostimulating activity. (C) 2001 Elsevier Science Ltd. All rights reserved. |
| WOS关键词 | ANTITUMOR-ACTIVITY ; DERIVATIVES ; POLYSACCHARIDES ; (1->3)-BETA-D-GLUCANS ; BEHAVIOR ; GLUCAN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000172090100005 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274430]  |
| 专题 | 药理学第三研究室 天然药物化学研究室 |
| 通讯作者 | Fang, JN |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, XF,Duan, JY,Fang, XY,et al. Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity[J]. CARBOHYDRATE RESEARCH,2001,336(2):127-140. |
| APA | Bao, XF,Duan, JY,Fang, XY,&Fang, JN.(2001).Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity.CARBOHYDRATE RESEARCH,336(2),127-140. |
| MLA | Bao, XF,et al."Chemical modifications of the (1 -> 3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity".CARBOHYDRATE RESEARCH 336.2(2001):127-140. |
入库方式： OAI收割
来源：上海药物研究所
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