Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum
文献类型：期刊论文
| 作者 | Bao, XF; Fang, JN; Li, XY |
| 刊名 | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
 |
| 出版日期 | 2001-11 |
| 卷号 | 65期号:11页码:2384-2391 |
| 关键词 | Ganoderma lucidum spores glucan antibody production lymphocyte proliferation |
| ISSN号 | 0916-8451 |
| DOI | 10.1271/bbb.65.2384 |
| 文献子类 | Article |
| 英文摘要 | A pole saccharide with a molecular weight of 1.26 x 10(5), obtained from the sporoderm-broken spores of Ganoderma lucidum, was purified by anion-exchange and gel-permeation chromatography. This polysaccharide had a strong effect on suppressing the antibody production and the Con A or LPS induced lymphocyte proliferation in mice. Chemically, the structure of the polysaccharide was identified by methylation analysis, 1 D, 2 D NNIR and ESI-MS spectroscopic studies of the native one and of the oligosaccharide fragments generated by partial acid hydrolysis, Smith degradation, and acetol sis. It was concluded that the intact polysaccharide was a complex beta -D-glucan consisting of a (1 -->6)linked backbone chain, in which every other glucosyl residue was substituted at C-3 or C-4 with mono-, di- and trisaccharide branches. |
| WOS关键词 | ANTITUMOR-ACTIVITY ; ALDITOL ACETATES ; POLYSACCHARIDES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000172497000003 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274433]  |
| 专题 | 药理学第三研究室 天然药物化学研究室 |
| 通讯作者 | Fang, JN |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, XF,Fang, JN,Li, XY. Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2001,65(11):2384-2391. |
| APA | Bao, XF,Fang, JN,&Li, XY.(2001).Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,65(11),2384-2391. |
| MLA | Bao, XF,et al."Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 65.11(2001):2384-2391. |
入库方式： OAI收割
来源：上海药物研究所
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