Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst
文献类型：期刊论文
| 作者 | Bao, XF; Liu, CP; Fang, JN; Li, XY |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2001-05-08 |
| 卷号 | 332期号:1页码:67-74 |
| 关键词 | fungus Ganoderma lucidum spores conformational analysis immunological activities |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/S0008-6215(01)00075-1 |
| 文献子类 | Article |
| 英文摘要 | A polysaccharide isolated from spores of the fungus, Ganoderma lucidum, was found to be a complex glucan. On the basis of compositional and methylation analyses, periodate oxidation, Smith degradation, 1D and 2D NMR, and ESIMS experiments of the native polysaccharide and its degraded products, the polysaccharide was shown to have a backbone of beta-(1 -->3)-linked D-glucopyranosyl residues, with branches of mono-, di- and oligosaccharide side chains substituting at the C-6 of the glucosyl residues in the main chain. Conformational analysis in aqueous solution and immunological activities of the native and degraded glucans were also investigated. The results suggested that the degree of substitution on the main chain and the length of side chains may be very important factors in determining the conformation and the biological activities of beta-(1 -->3)-linked glucans. (C) 2001 Elsevier Science Ltd. All rights reserved. |
| WOS关键词 | ANTI-TUMOR POLYSACCHARIDE ; ANTITUMOR-ACTIVITY ; ALDITOL ACETATES ; (1->3)-BETA-D-GLUCANS ; FEATURES ; GLUCAN ; ROOTS ; MICE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000168794400006 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274492]  |
| 专题 | 天然药物化学研究室 药理学第三研究室 |
| 通讯作者 | Fang, JN |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, XF,Liu, CP,Fang, JN,et al. Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst[J]. CARBOHYDRATE RESEARCH,2001,332(1):67-74. |
| APA | Bao, XF,Liu, CP,Fang, JN,&Li, XY.(2001).Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst.CARBOHYDRATE RESEARCH,332(1),67-74. |
| MLA | Bao, XF,et al."Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst".CARBOHYDRATE RESEARCH 332.1(2001):67-74. |
入库方式： OAI收割
来源：上海药物研究所
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