Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, ZT; Zhu, XZ |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2000-06-08 |
| 卷号 | 67期号:3页码:241-250 |
| 关键词 | L-deprenyl MPP+ (1-methyl-4-phenylpyridinium ion) MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) striatum nucleus accumbens microdialysis |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/S0024-3205(00)00628-7 |
| 文献子类 | Article |
| 英文摘要 | The present studies investigated the effects of L-deprenyl, 1-methyl-4-phenylpyridinium ion (MPP+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the efflux of dopamine and its metabolites in microdialysates of striatum and nucleus accumbens in rats. L-Deprenyl or L-amphetamine perfusion into striatum had no effects on basal dopamine efflux, though L-deprenyl reduced the basal efflux of dihydroxyphenylacetic acid and homovanillic acid. MPP+ or MPTP perfusion into striatum significantly increased the dopamine efflux, and the action of MPTP was more potent than that of MPP+. Pretreatment with L-deprenyl antagonized the actions of MPP+ and MPTP. The striatal dopamine efflux of rats was gradually restored by itself after the overflow caused by 2-h perfusion of the dopaminergic neurotoxins, while L-deprenyl could not accelerate the recovery. Perfusion with L-deprenyl or L-amphetamine, but not pargyline, into nucleus accumbens increased the dopamine efflux in a dose-dependent fashion, which could be antagonized by haloperidol pretreatment, MPP+ or MPTP perfusion into nucleus accumbens also increased the dopamine efflux, and the action of MPTP was also more potent than that of MPP+. Pretreatment with L-deprenyl could not antagonize the actions of MPP+ and MPTP. These findings suggest that L-deprenyl, MPP+ and MPTP induce differential effects on nigrostriatal and mesolimbic dopaminergic pathways in vivo. L-Deprenyl has neuroprotective rather than neurorestorative action against MPP+- and MPTP-induced dopamine overflow from striatum. Further, L-deprenyl-induced dopamine overflow from nucleus accumbens may explain the amphetamine-like reinforcing property of L-deprenyl. (C) 2000 Elsevier Science Inc. All rights reserved. |
| WOS关键词 | SELEGILINE ; NEUROTOXICITY ; NEUROTENSIN ; PATHWAYS ; TOXICITY ; SYSTEMS ; RAT |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000087709700004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274609]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Wu, WR |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, ZT,Zhu, XZ. Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens[J]. LIFE SCIENCES,2000,67(3):241-250. |
| APA | Wu, WR,Zhu, ZT,&Zhu, XZ.(2000).Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens.LIFE SCIENCES,67(3),241-250. |
| MLA | Wu, WR,et al."Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens".LIFE SCIENCES 67.3(2000):241-250. |
入库方式： OAI收割
来源：上海药物研究所
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