Behavioral characteristics of olanzapine: an atypical neuroleptic
文献类型：期刊论文
| 作者 | Fu, Y; Zhu, ZT; Chen, LJ; Yu, LP; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-04 |
| 卷号 | 21期号:4页码:329-334 |
| 关键词 | olanzapine antipsychotic agents dopamine avoidance learning catalepsy electrophysiology substantia nigra ventral tegmental area |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To assess the atypical neuroleptic properties of a novel antipsychotic agent, olanzapine (Ola). METHODS: The action of Ola on apomorpine (Apo)-induced climbing behavior, 5-hydroxy-dl-tryptophan (5-HTP)induced head twitch response, oxotremorine-induced tremor, and the conditioned avoidance behavior in mice were observed. The catalepsy of mice induced by Ola was also investigated. The single unit extracellular recording technique was used to compare the spontaneous firing rate changes of dopamine (DA) cells in the ventral tegmental area (VTA, A(10)) and the substantia nigra pars compact (SNC, A(9)) in rats after iv Ola. RESULTS: Ola antagonized the climbing behavior (ED50 18 mg.kg(-1), po), head twitch behavior (ED50 0.3 mg.kg(-1) po), and tremor (ED50 5.2 mg.kg(-1), po) in mice. In a conditioned avoidance paradigm in mice, Ola inhibited the avoidance response with an ED50 of 2.72 mg.kg(-1) (po). However, the catalepsy was not induced by Ola in mice even under a very high dose of 100 mg.kg(-1) (po). Ola selectively increased the firing rate of DA cells in the VTA, but failed to affect that of SNC DA cells. CONCLUSION: Ola distinguished itself from the typical neuroleptic leg haloperidol, Hall and took resemblance of the atypical neuroleptic (eg clozapine, Clo) in 3 aspects: 1) the multiple receptor pharmacodynamics involving D-1/D-2, 5-HT2 and M-ACh receptors; 2) dose-response separation between the block of conditioned avoidance response and catalepsy induction; and 3) the specificity of action sites of firing rates upon acute drug challenge. |
| WOS关键词 | ANTIPSYCHOTIC-DRUGS ; DOPAMINE NEURONS ; HALOPERIDOL ; MECHANISMS ; CATALEPSY ; RECEPTORS ; A10 ; RAT ; D-1 ; A9 |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:510047 |
| WOS记录号 | WOS:000086478800010 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274628]  |
| 专题 | 院士及顾问专家 药理学第二研究室 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Y,Zhu, ZT,Chen, LJ,et al. Behavioral characteristics of olanzapine: an atypical neuroleptic[J]. ACTA PHARMACOLOGICA SINICA,2000,21(4):329-334. |
| APA | Fu, Y,Zhu, ZT,Chen, LJ,Yu, LP,&Jin, GZ.(2000).Behavioral characteristics of olanzapine: an atypical neuroleptic.ACTA PHARMACOLOGICA SINICA,21(4),329-334. |
| MLA | Fu, Y,et al."Behavioral characteristics of olanzapine: an atypical neuroleptic".ACTA PHARMACOLOGICA SINICA 21.4(2000):329-334. |
入库方式： OAI收割
来源：上海药物研究所
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