Atypical antipsychotic effects of quetiapine fumarate in animal models
文献类型：期刊论文
| 作者 | Guan, HJ; Dai, J; Zhu, XZ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-03 |
| 卷号 | 21期号:3页码:205-210 |
| 关键词 | quetiapine fumarate clozapine haloperidol antipsychotic agents phencyclidine swimming depression schizophrenia and disorders with psychotic features basal ganglia diseases |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To evaluate the effect of quetiapine fumarate in animal models of schizophrenia and its possibility to induce extrapyramidal side effects(EPSE). METHODS: The enhancement of immobility in a forced swimming test of mice induced by repeated treatment with phencyclidine and amphetamine swimming "normalization" test of mice were used as animal models of negative and positive symptoms of schizophrenia, respectively. The paw test of rats was used to evaluate the possibility by quetiapine fumarate to induce EPSE. RESULTS: After treatment with phencyclidine (10 mg.kg(-1).d(-1), sc, 14 d), the immobility time in the forced swimming test of mice was increased (P < 0.01). Quetiapine fumarate (20, 40, and 80 mg.kg(-1), ig) and clozapine (10 and 30 mg.kg(-1), ig) attenuated the enhanced immobility an the forced swimming test induced by repeated treatment with phencyclidine ( P < 0.01), whereas haloperidol (0.3 and 1 mg.kg(-1), ig) had no effect. In amphetamine swimming "normalization" test, quetiapine fumarate ameliorated the disorder induced by amphetamine in a dose-dependent manner. In paw test, quetiapine fumarate was much less effective in increasing the forelimb retraction time (FRT) than the hindlimb retraction time (HRT). The minimal effective dose (MED) of HRT (MEDHRT) and FRT (MEDFRT) Of quetiapine fumarate was 20 mg kg(-1) and 100 mg.kg(-1), respectively, and the ratio of MEDFRT to MEDHRT was 5. CONCLUSION: The effects of quetiapine fumarate in these models indicated its clinical effect on schizophrenia with a reduced liability to produce EPSE. |
| WOS关键词 | NEUROLEPTIC DRUGS ; PAW TEST ; SCHIZOPHRENIA ; SEROQUEL ; PHENCYCLIDINE ; ICI-204-636 ; EFFICACY ; SAFETY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000085838400003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274636]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol 1, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, HJ,Dai, J,Zhu, XZ. Atypical antipsychotic effects of quetiapine fumarate in animal models[J]. ACTA PHARMACOLOGICA SINICA,2000,21(3):205-210. |
| APA | Guan, HJ,Dai, J,&Zhu, XZ.(2000).Atypical antipsychotic effects of quetiapine fumarate in animal models.ACTA PHARMACOLOGICA SINICA,21(3),205-210. |
| MLA | Guan, HJ,et al."Atypical antipsychotic effects of quetiapine fumarate in animal models".ACTA PHARMACOLOGICA SINICA 21.3(2000):205-210. |
入库方式： OAI收割
来源：上海药物研究所
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