Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes
文献类型：期刊论文
| 作者 | Zheng, SX; Zhou, LJ; Chen, ZL; Yin, ML; Zhu, XZ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-02 |
| 卷号 | 21期号:2页码:151-155 |
| 关键词 | Ginkgo biloba neurotrophin astrocytes up-regulation (physiology) reverse transcriptase polymerase chain reaction immunohistochemistry bilobalide |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of bilobalide on the expression of glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF) in rat astrocytes in vitro. METHODS: Semiquantification polymerase chain reaction (SQ-PCR) was used to investigate GDNF and VEGF mRNA expression in the astrocytes after bilobalide (5, 15, 50, 100 mu mol.L-1) treatment. Immunohistochemistry method was used to detect GDNF and VEGF protein expression in cells treated with bilobalide 50 mu mol.L-1 for 24 h. RESULTS: GDNF and VEGF mRNA increased markedly after astrocytes were treated With bilobalide 50 mu mol.L-1 for 12 h. GDNF and VEGF protein were detected in the cytoplasm of astrocytes after the cells were treated with bilobalide 50 mu mol.L-1 for 24 h. CONCLUSION: Bilobalide induced GDNF and VEGF expression in the cultured astrocytes. |
| WOS关键词 | GINKGO-BILOBA ; EXTRACT EGB-761 ; BRAIN ; DEMENTIA ; DISEASE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000085208200008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274646]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, SX,Zhou, LJ,Chen, ZL,et al. Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes[J]. ACTA PHARMACOLOGICA SINICA,2000,21(2):151-155. |
| APA | Zheng, SX,Zhou, LJ,Chen, ZL,Yin, ML,&Zhu, XZ.(2000).Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes.ACTA PHARMACOLOGICA SINICA,21(2),151-155. |
| MLA | Zheng, SX,et al."Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes".ACTA PHARMACOLOGICA SINICA 21.2(2000):151-155. |
入库方式： OAI收割
来源：上海药物研究所
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