Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, XZ |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 1999-06-04 |
| 卷号 | 65期号:2页码:157-164 |
| 关键词 | Ginkgo biloba extract ginkgolide A ginkgolide B MPTP dopamine striatum HPLC kynuramine 4-hydroxyquinoline monoamine oxidase fluorescence |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/S0024-3205(99)00232-5 |
| 文献子类 | Article |
| 英文摘要 | The present study investigated the neuroprotective and neurorestorative effects of Ginkgo biloba extract (EGb 761) and its two components ginkgolides A (BN52020) and B (BN52021) in mice, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg/kg/d ip for six days) significantly reduced striatal dopamine (DA) levels in C57 mice measured by high performance liquid chromatography with electrochemical detection (HPLC-EC). When C57 mice were pretreated with EGb 761 (20, 50, 100 mg/kg/d ip) for 7 days and then treated with the same extract 30 min before MPTP injection for 6 days, the neurotoxic effect of MPTP was antagonized in a dose-dependent fashion. Similar treatment with ginkgolides A and B (5, 10, 50 mg/kg/d ip) showed no protective effect. When C57 mice were treated with EGb 761 (50 mg/kg/d ip) after MPTP-lesion, the recovery of striatal dopamine (DA) levels was accelerated. However, similar treatment with ginkgolides A or B (10 mg/kg/d ip) did not show any effect. EGb 761, but not ginkgolides A and B, nonselectively inhibited mouse brain MAO activity in vitro (IC(50) = 36.45 +/- 1.56 mu g/ml) tested by an improved fluorimetric assay. The results demonstrate that EGb 761 administered before or after MPTP treatment effectively protects against MPTP-induced nigrostriatal dopaminergic neurotoxicity and that the inhibitory effect of EGb 761 on brain MAO may be involved in its neuroprotective effect. |
| WOS关键词 | PLATELET-ACTIVATING-FACTOR ; NEUROTOXICITY ; PARKINSONISM ; EFFICACY ; DISEASE |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000080855800005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274718]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, XZ. Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice[J]. LIFE SCIENCES,1999,65(2):157-164. |
| APA | Wu, WR,&Zhu, XZ.(1999).Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice.LIFE SCIENCES,65(2),157-164. |
| MLA | Wu, WR,et al."Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice".LIFE SCIENCES 65.2(1999):157-164. |
入库方式： OAI收割
来源：上海药物研究所
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