Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against MPTP-induced dopaminergic toxicity
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, XZ; Guan, HJ; Wang, RG; Ji, XQ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-02 |
| 卷号 | 20期号:2页码:146-150 |
| 关键词 | selegiline dopamine corpus striatum high pressure liquid chromatography kynuramine quinolines monoamine oxidase fluorometry 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine inbred C57BL mice |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the neuroprotective, neurorescue, neurorestorative effects of selegiline (Sel) on nigrostriatal dopaminergic neuronal system and its inhibition of brain monoamine oxidase B (MAO-B). METHODS: The striatal levels of dopamine and its metabolites were measure using HPLC with electrochemical detection (HPLC-EC). The inhibition of MAO-B was tested by an improved fluorimetric assay. RESULTS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) (30 mg . kg(-1) ip) reduced the striatal dopamine level by 73% in mice. Selegiline (Sel, 10 mg . kg(-1) ip) before, but not after, MPTP treatment protected against MPTP-induced nigrostriatal dopaminergic neurotoxicity. There were no differential effects between Sel and saline treatments on the recovery of striatal dopamine levels, which were partially restored during 2 wk. 1-Methyl-4-phenylpyridinium) (MPP+) (5 mg . kg(-1) ip) produced no dopaminergic neurotoxicity. Furthermore, Sel selectively and irreversibly inhibited mouse brain MAO-B in vitro (IC50 = 17 nmol.L-1, 95% confidence limits = 14 - 20 nmol.L-1). CONCLUSION: Selegiline has neuroprotective rather than neurorescue or neurorestorative effects on MPTP-induced nigrostriatal dopaminergic neuronal degeneration, which is directly pertinent to its selective and irreversible inhibition of brain MAO-B activity. |
| WOS关键词 | L-DEPRENYL SELEGILINE ; PARKINSONS-DISEASE ; B INHIBITOR ; NEUROTOXICITY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000078533100011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274756]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, XZ,Guan, HJ,et al. Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against MPTP-induced dopaminergic toxicity[J]. ACTA PHARMACOLOGICA SINICA,1999,20(2):146-150. |
| APA | Wu, WR,Zhu, XZ,Guan, HJ,Wang, RG,&Ji, XQ.(1999).Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against MPTP-induced dopaminergic toxicity.ACTA PHARMACOLOGICA SINICA,20(2),146-150. |
| MLA | Wu, WR,et al."Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against MPTP-induced dopaminergic toxicity".ACTA PHARMACOLOGICA SINICA 20.2(1999):146-150. |
入库方式： OAI收割
来源：上海药物研究所
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