Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in Macaca mulatta
文献类型：期刊论文
| 作者 | Wang, RG; Zhu, XZ; Song, W |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-01 |
| 卷号 | 19期号:1页码:50-53 |
| 关键词 | recombinant granulocyte macrophage colony-stimulating factor enzyme-linked immunosorbent assay pharmacokinetics Macaca mulatta |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To examine the pharmacokinetics of iv and sc recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) in Macaca mulatta. METHODS: Plasma levels of rhGM-CSF were detected with sandwich enzyme-linked immunosorbent assay. RESULTS: Plasma concentration-time curves after iv rhGM-CSF in monkeys were best fitted with 3-compartment model. The 1st, 2nd, and 3rd phase T1/2 were 0.05-0.07, 0.14-0.58, and 1.4-4.1 h. Cl and K-10 were similar between different doses, respectively. C-max was 0.93 +/- 0.16 mu g.L-1, T-max was 2.65 +/- 0.14 h, and elimination T1/2 was 2.5 +/- 0.3 h after: sc rhGM-CSF. The bioavailability after sc rhGM-CSF was 0.61. CONCLUSION: Pharmacokinetics of rhGM-CSF in Macaca mulatta provided a useful index for clinical trial. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000071424500013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274868]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, RG,Zhu, XZ,Song, W. Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in Macaca mulatta[J]. ACTA PHARMACOLOGICA SINICA,1998,19(1):50-53. |
| APA | Wang, RG,Zhu, XZ,&Song, W.(1998).Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in Macaca mulatta.ACTA PHARMACOLOGICA SINICA,19(1),50-53. |
| MLA | Wang, RG,et al."Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in Macaca mulatta".ACTA PHARMACOLOGICA SINICA 19.1(1998):50-53. |
入库方式： OAI收割
来源：上海药物研究所
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