Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices
文献类型：期刊论文
| 作者 | Ma, TC; Zhu, XZ |
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1997-03-05 |
| 卷号 | 321期号:3页码:343-347 |
| 关键词 | nitric oxide (NO) cGMP interleukin-6 hippocampus sodium nitroprusside N-G-nitro-L-arginine |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/S0014-2999(96)00955-7 |
| 文献子类 | Article |
| 英文摘要 | We examined the effect of interleukin-6 on the levels of cGMP and nitrite in rat hippocampal slices. Interleukin-6 at 400 ng/ml time dependently increased the content of cGMP of slices after incubation for 1, 2, 3, and 4 h, and the effect of interleukin-6 was maximal at 2 h post-incubation. In addition, exposure of slices to interleukin-6 at 80, 400 and 2000 ng/ml or at 16, 80 and 400 ng/ml for 2 h significantly elevated the cGMP level and nitrite level, respectively, in a concentration-dependent manner. Also, 0.1 mM N-G-nitro-L-arginine alone showed no effect on either the cGMP level or the nitrite level. However when incubated in conjunction with 400 ng/ml interleukin-6 for 2 h, N-G-nitro-L-arginine apparently prevented the increase in cGMP and nitrite induced by 400 ng/ml interleukin-6. The present results show that NO mediates the increase in cGMP induced by interleukin-6 and suggest that interleukin-6 may exert an inducible effect on the NO synthase in hippocampal slices. |
| WOS关键词 | FOCAL CEREBRAL-ISCHEMIA ; NECROSIS-FACTOR-ALPHA ; CYTOKINE PRODUCTION ; OXIDE ; IL-1-BETA ; NEURONS ; BRAIN ; NO ; ASTROCYTES ; INHIBITOR |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997WM97800011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274917]  |
| 专题 | 药理学第二研究室 |
| 作者单位 | CHINESE ACAD SCI, SHANGHAI INST MAT MED, DEPT PHARMACOL, SHANGHAI 200031, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Ma, TC,Zhu, XZ. Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1997,321(3):343-347. |
| APA | Ma, TC,&Zhu, XZ.(1997).Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices.EUROPEAN JOURNAL OF PHARMACOLOGY,321(3),343-347. |
| MLA | Ma, TC,et al."Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices".EUROPEAN JOURNAL OF PHARMACOLOGY 321.3(1997):343-347. |
入库方式： OAI收割
来源：上海药物研究所
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