EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes
文献类型：期刊论文
| 作者 | Jiang, Yiqun3,7,8; Mao, Chao7,8; Yang, Rui7,8; Yan, Bin1,7,8; Shi, Ying7,8; Liu, Xiaoli7,8; Lai, Weiwei7,8; Liu, Yating7,8; Wang, Xiang3; Xiao, Desheng4 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:13页码:3293-3305 |
| 关键词 | Ferroptosis LSH WDR76 EGLN1 PHD2 c-Myc HIF-1 alpha SCD1 FADS2 Iron Lipid reactive oxygen species Metabolism Lung cancer |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.19988 |
| 文献子类 | Article |
| 英文摘要 | Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis by activating lipid metabolism-associated genes, including GLUT1, and ferroptosis related genes SCD1 and FADS2, in turn, involved in the Warburg effect. WDR76 targeted these genes expression in dependent manner of LSH and chromatin modification in DNA methylation and histone modification. These effects were dependent on iron and lipid reactive oxygen species. We further demonstrated that EGLN1 and c-Myc directly activated the expression of LSH by inhibiting HIF-1 alpha. Finally, we demonstrated that LSH functioned as an oncogene in lung cancer in vitro and in vivo. Therefore, our study elucidates the molecular basis of the c-Myc/EGLN1-mediated induction of LSH expression that inhibits ferroptosis, which can be exploited for the development of therapeutic strategies targeting ferroptosis for the treatment of cancer. |
| WOS关键词 | CELL LUNG-CANCER ; DNA METHYLATION ; C-MYC ; CHROMATIN ; LSH ; HIF ; TUMOR ; HYPOXIA ; FAMILY ; PROLIFERATION |
| 资助项目 | National Basic Research Program of China[2015CB553903] ; National Natural Science Foundation of China[81372427] ; National Natural Science Foundation of China[81672787] ; National Natural Science Foundation of China[81271763] ; National Natural Science Foundation of China[81672991] ; National Natural Science Foundation of China[81302354] ; National Natural Science Foundation of China[81672307] ; National Natural Science Foundation of China[81422051] ; National Natural Science Foundation of China[81472593] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000406499400008 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275705]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Tao, Yongguang |
| 作者单位 | 1.Cent S Univ, Inst Med Sci, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Cent S Univ, Dept Thorac Surg, Xiangya Hosp 2, Changsha, Hunan, Peoples R China; 4.Cent S Univ, Dept Pathol, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; 5.Yale Sch Med, Dept Pathol, New Haven, CT 06520 USA 6.Cent S Univ, Dept Pharmacol, Sch Pharmaceut Sci, Changsha 410078, Hunan, Peoples R China; 7.Cent S Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; 8.Cent S Univ, Canc Res Inst, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jiang, Yiqun,Mao, Chao,Yang, Rui,et al. EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes[J]. THERANOSTICS,2017,7(13):3293-3305. |
| APA | Jiang, Yiqun.,Mao, Chao.,Yang, Rui.,Yan, Bin.,Shi, Ying.,...&Tao, Yongguang.(2017).EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes.THERANOSTICS,7(13),3293-3305. |
| MLA | Jiang, Yiqun,et al."EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes".THERANOSTICS 7.13(2017):3293-3305. |
入库方式： OAI收割
来源：上海药物研究所
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