Metabolic profiling: shedding new light on the pathophysiological process and prognosis of HBV-related acute-on-chronic liver failure
文献类型：期刊论文
| 作者 | Ji, Liujuan2; Liu, Xia1 ; Liu, Yu2; Zhu, Hui2; Zhang, Yuyi2; Zhang, Zhengguo2; Guo, Hongying2; Yuan, Wei2; Qian, Zhiping2; Zhang, Naixia1
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| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
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| 出版日期 | 2017 |
| 卷号 | 10期号:5页码:7597-+ |
| 关键词 | Metabolic profiling HBV ACLF outcome prediction discriminative metabolite |
| ISSN号 | 1940-5901 |
| 文献子类 | Article |
| 英文摘要 | Severe global metabolic deterioration is a key feature of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). To investigate the global metabolic changes of HBV-ACLF patients and explore the prognostic potential, extracted metabolic profiling information will shed new light on the pathophysiological process and prognosis of this disease. An NMR-based metabolomics study and its coupled survival prediction ability analysis were applied to the serum samples of healthy controls (HC, n=23), chronic hepatitis B patients (CHB, n=27), surviving HBV-ACLF patients (ACLF-S, n=24) and non-surviving HBV-ACLF patients (ACLF-NS, n=30). The score plots from the metabolomics analysis reveal clear metabolic separations of the HBV-ACLF patients from the CHB individuals and of the surviving HBV-ACLF individuals from the non-surviving ones. Ultimately, 14 discriminative metabolites, including lipids, LDL and twelve amino acids, presented consecutive changes with the progression of HBV-ACLF. These metabolites potentially play important roles in the progression of HBV-ACLF. The averaged sensitivity and specificity values of the survival prediction models based on metabolomics data are 76.7% and 83.3%, respectively. The combined use of metabolomics data and clinical parameters raises the sensitivity and specificity values of the predicted score plot up to 91.7% and 90%, respectively. The phenotypic metabolomics analyses of HC, CHB, ACLF, ACLF-S and ACLF-NS individuals provides an encouraging basis for deeper studies of the HBV-ACLF pathophysiological process and demonstrates a proof of concept that global metabolic profiling data is a reliable source to improve the accuracy of predicting the survival outcome of HBV-ACLF patients. |
| WOS关键词 | FULMINANT HEPATIC-FAILURE ; PLASMA AMINO-ACID ; H-1-NMR SPECTROSCOPY ; CIRRHOSIS ; GLUTAMINE ; DISEASE ; BRAIN ; SERUM ; MODEL ; MELD |
| 资助项目 | Ministry of Science and Technology of China[2012ZX10005] ; science foundation for youth of Shanghai Municipal Health Bureau[20134y011] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000402294200027 |
| 出版者 | E-CENTURY PUBLISHING CORP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275714]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Qian, Zhiping; Zhang, Naixia; Wang, Jiefei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Liver Intens Care Unit, Shanghai 201508, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ji, Liujuan,Liu, Xia,Liu, Yu,et al. Metabolic profiling: shedding new light on the pathophysiological process and prognosis of HBV-related acute-on-chronic liver failure[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2017,10(5):7597-+. |
| APA | Ji, Liujuan.,Liu, Xia.,Liu, Yu.,Zhu, Hui.,Zhang, Yuyi.,...&Wang, Jiefei.(2017).Metabolic profiling: shedding new light on the pathophysiological process and prognosis of HBV-related acute-on-chronic liver failure.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,10(5),7597-+. |
| MLA | Ji, Liujuan,et al."Metabolic profiling: shedding new light on the pathophysiological process and prognosis of HBV-related acute-on-chronic liver failure".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 10.5(2017):7597-+. |
入库方式： OAI收割
来源：上海药物研究所
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