The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents
文献类型：期刊论文
| 作者 | Zhang, Nan2; Zhang, Lei1; Feng, Linyin1 ; Yao, Lei2
|
| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2016-12-15 |
| 卷号 | 23期号:14页码:1727-1734 |
| ISSN号 | 0944-7113 |
| 关键词 | Cananga odorata Anxiolytic effect Benzyl benzoate Dopamine Serotonin |
| DOI | 10.1016/j.phymed.2016.10.017 |
| 文献子类 | Article |
| 英文摘要 | Background: Essential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. Hypothesis/Purpose: To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. Study design and methods: ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure. Main constituents of YYO were defined using GC/MS. These compounds were then tested on the male mice separately on three anxiety models. The monoamines neurotransmitters and their metabolites were analyzed after acute odor exposure and elevated plus maze test. Results: YYO exposure only showed significant anxiolytic effect on the male mice. It increased the time that mice visited open arms and light box area in elevated plus maze and light-dark box tests after acute and chronic YYO exposures. Three main constituents of YYO, benzyl benzoate, linalool and benzyl alcohol showed anxiolytic effect on the male mice individually. YYO exposure brought changes of neurotransmitters on the male mice more significantly than the female mice. It decreased the dopamine (DA) concentration in the striatum and increased the 5-hydroxytryptamine (5-HT) concentration in the hippocampus of the male mice. The major constituent benzyl benzoate changed neurotransmitters concentration in accordance with the YYO. Moreover, it decreased the ratio of 5-HIAA/5-HT in the hippocampus. Conclusion: Both acute and chronic YYO exposure showed anxiolytic effect on the male mice. YYO and its major constituent benzyl benzoate might act on the 5-HTnergic and DAnergic pathways. (C) 2016 Elsevier GmbH. All rights reserved. |
| WOS关键词 | ANIMAL-MODELS ; LAVENDER OIL ; YLANG-YLANG ; INHALATION ; ANXIETY ; BEHAVIOR ; RECEPTORS ; SYSTEM ; 5-HT |
| 资助项目 | Shanghai Jiaotong University[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| 出版者 | ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| WOS记录号 | WOS:000389207800004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275762]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Feng, Linyin; Yao, Lei |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Receptor Res, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Nan,Zhang, Lei,Feng, Linyin,et al. The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents[J]. PHYTOMEDICINE,2016,23(14):1727-1734. |
| APA | Zhang, Nan,Zhang, Lei,Feng, Linyin,&Yao, Lei.(2016).The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents.PHYTOMEDICINE,23(14),1727-1734. |
| MLA | Zhang, Nan,et al."The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents".PHYTOMEDICINE 23.14(2016):1727-1734. |
入库方式： OAI收割
来源：上海药物研究所
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