Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease
文献类型：期刊论文
| 作者 | Mottawea, Walid2,3,4; Chiang, Cheng-Kang2,3; Muelbauer, Marcus5; Starr, Amanda E.2,3; Butcher, James2,3; Abujamel, Turki2,3; Deeke, Shelley A.2,3; Brandel, Annette2,3; Zhou, Hu3,6 ; Shokralla, Shadi7
|
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2016-11-23 |
| 卷号 | 7 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms13419 |
| 文献子类 | Article |
| 英文摘要 | Intestinal microbial dysbiosis is associated with Crohn's disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that characterizes this disease remain unclear. In this report, we use systems-level approaches to study the interactions between the gut microbiota and host in new-onset paediatric patients to evaluate causality and mechanisms of disease. We report an altered host proteome in CD patients indicative of impaired mitochondrial functions. In particular, mitochondrial proteins implicated in H2S detoxification are downregulated, while the relative abundance of H2S microbial producers is increased. Network correlation analysis reveals that Atopobium parvulum controls the central hub of H2S producers. A. parvulum induces pancolitis in colitis-susceptible interleukin-10-deficient mice and this phenotype requires the presence of the intestinal microbiota. Administrating the H2S scavenger bismuth mitigates A. parvulum-induced colitis in vivo. This study reveals that host-microbiota interactions are disturbed in CD and thus provides mechanistic insights into CD pathogenesis. |
| WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; COA-TRANSFERASE GENES ; ULCERATIVE-COLITIS ; CAMPYLOBACTER-JEJUNI ; HYDROGEN-SULFIDE ; PROSPECTIVE MULTICENTER ; BARRIER DYSFUNCTION ; NONINFLAMED ILEUM ; ENTERAL NUTRITION ; INTERACTIVE TREE |
| 资助项目 | Government of Canada through Genome Canada[00000000] ; Ontario Genomics Institute[OGI-067] ; CIHR[GPH-129340] ; CIHR[MOP-114872] ; CIHR[117960-1] ; Ontario Ministry of Economic Development and Innovation[REG1-4450] ; IBD foundation[00000000] ; Crohn's and Colitis Canada (CCC)[00000000] ; CHEO foundation[00000000] ; Children's Hospital of Eastern Ontario Research Institute[00000000] ; Faculty of Medicine of the University of Ottawa[00000000] ; NIH[R01 DK73338] ; NIH[R01 DK47700] ; NIH[R21 CA195226] ; CGIBD[P30 DK034987] ; Mansoura University, Egypt[00000000] ; King Abdulaziz University through the Saudi Arabian Cultural Bureau in Canada[00000000] ; CCFA[00000000] ; Canadian Child Health Clinician Scientist Program[00000000] ; Canadian Institutes of Health Research[00000000] ; Canadian Association of Gastroenterology[00000000] ; Crohn's and Colitis Canada[00000000] ; CIHR/CAG/CCC Postdoctoral Award[00000000] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000388319900001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275800]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Jobin, Christian; Mack, David R.; Stintzi, Alain |
| 作者单位 | 1.Univ Ottawa, Sch Epidemiol Publ Hlth & Prevent Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; 2.Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; 3.Univ Ottawa, Ottawa Inst Syst Biol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; 4.Mansoura Univ, Fac Pharm, Dept Microbiol & Immunol, Mansoura 35516, Egypt; 5.Univ Florida, Dept Med, Div Gastroenterol Hepatol & Nutr, Gainesville, FL 32611 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 7.Univ Guelph, Biodivers Inst Ontario, Dept Integrat Biol, Guelph, ON N1G 2W1, Canada; 8.Childrens Hosp Eastern Ontario, Ctr Inflammatory Bowel Dis, 451 Smyth Rd, Ottawa, ON K1H 8L1, Canada; 9.CHEO, Res Inst, 451 Smyth Rd, Ottawa, ON K1H 8L1, Canada; 10.Univ Ottawa, Dept Pediat, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada; |
| 推荐引用方式 GB/T 7714 | Mottawea, Walid,Chiang, Cheng-Kang,Muelbauer, Marcus,et al. Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease[J]. NATURE COMMUNICATIONS,2016,7. |
| APA | Mottawea, Walid.,Chiang, Cheng-Kang.,Muelbauer, Marcus.,Starr, Amanda E..,Butcher, James.,...&Stintzi, Alain.(2016).Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease.NATURE COMMUNICATIONS,7. |
| MLA | Mottawea, Walid,et al."Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease".NATURE COMMUNICATIONS 7(2016). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。