Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana
文献类型：期刊论文
| 作者 | Liu, Qianyu1; Li, Dan1; Wang, Anqi1; Dong, Zhen2; Yin, Sheng2; Zhang, Qingwen1; Ye, Yang3 ; Li, Liangchun4; Lin, Ligen1
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2016-11 |
| 卷号 | 131页码:115-123 |
| 关键词 | Garcinia mangostana Clusiaceae Xanthones Dimeric xanthones NO inhibition iNOS |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2016.08.007 |
| 文献子类 | Article |
| 英文摘要 | Mangosteen (Garcinia mangostana, Clusiaceae) is called "queen of fruit" in Southeast Asia. In the current study, three dimeric xanthones, garcinoxanthones A-C, and four monomeric xanthones, garcinoxanthones D-G, together with 18 known xanthones, were isolated from the pericarps of G. mangostana, collected in Thailand. The structures of garcinoxanthones A G were elucidated by analysis of their 1D and 2D NMR and other spectroscopic data, and their absolute configurations were determined by the CD spectra. All seven compounds were tested for nitric oxide (NO) inhibitory activity on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Garcinoxanthones B and C significantly inhibited NO production with IC50 values of 11.3 +/- 1.7 and 18.0 +/- 1.8 mu M, respectively, which were comparable with the positive control indomethacin (IC50 3.9 +/- 0.3 mu M). Moreover, garcinoxanthone B suppressed inducible NO synthase expression in a dose-dependent manner. These results reveal the presence of rare dimeric xanthones in G. mangostana and their NO inhibitory effect on LPS-stimulated murine macrophage cells. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ANTIINFLAMMATORY ACTIVITY ; IN-VITRO ; CONSTITUENTS ; INSIGHTS ; BARK ; COWA |
| 资助项目 | Science and Technology Development Fund, Macao S.A.R[FDCT 120/2013/A3] ; University of Macau[MYRG2014-00020-ICMS-QRCM] ; University of Macau[MYRG2015-00153-ICMS-QRCM] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000385692000013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275842]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Li, Liangchun; Lin, Ligen |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; 2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 4.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621010, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qianyu,Li, Dan,Wang, Anqi,et al. Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana[J]. PHYTOCHEMISTRY,2016,131:115-123. |
| APA | Liu, Qianyu.,Li, Dan.,Wang, Anqi.,Dong, Zhen.,Yin, Sheng.,...&Lin, Ligen.(2016).Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana.PHYTOCHEMISTRY,131,115-123. |
| MLA | Liu, Qianyu,et al."Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana".PHYTOCHEMISTRY 131(2016):115-123. |
入库方式： OAI收割
来源：上海药物研究所
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