Design and synthesis of new tetrandrine derivatives and their antitumor activities
文献类型：期刊论文
| 作者 | Wei, Xiao2; Qu, Ting-Li2; Yang, Yi-Fang1; Xu, Jin-Fang2; Li, Xu-Wen3 ; Zhao, Zheng-Bao2; Guo, Yue-Wei3
|
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 18期号:10页码:966-975 |
| 关键词 | Tetrandrine Suzuki coupling synthesis antitumor activity structure-activity relationship |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2016.1188085 |
| 文献子类 | Article |
| 英文摘要 | A series of tetrandrine derivatives were designed and synthesized using Suzuki coupling reaction. Eleven targeted compounds with over 50% inhibition against HL60 and A549 human cancer cell lines at 10M were further evaluated for the in vitro antitumor activities by MTT or SRB assay. The biological results revealed that some compounds exhibited potent antitumor activities. Thiophene derivative 6 and acetylphenyl derivative 5 were the most active ones against HL60 and A549 cell lines, with IC50 values less than 5M, which thus could be considered as useful candidate for further development of new antitumor agents. |
| WOS关键词 | ACID-ESTER DERIVATIVES ; MULTIDRUG-RESISTANCE ; BISBENZYLISOQUINOLINE ALKALOIDS ; BIOLOGICAL EVALUATION ; APOPTOSIS ; CANCER ; CELLS |
| 资助项目 | 11th Five Plan for Significant Formulation of New Drugs[2009ZX09301-007] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[8130269241476063] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000381494000008 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276209]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Zhao, Zheng-Bao; Guo, Yue-Wei |
| 作者单位 | 1.Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China; 2.Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xiao,Qu, Ting-Li,Yang, Yi-Fang,et al. Design and synthesis of new tetrandrine derivatives and their antitumor activities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18(10):966-975. |
| APA | Wei, Xiao.,Qu, Ting-Li.,Yang, Yi-Fang.,Xu, Jin-Fang.,Li, Xu-Wen.,...&Guo, Yue-Wei.(2016).Design and synthesis of new tetrandrine derivatives and their antitumor activities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18(10),966-975. |
| MLA | Wei, Xiao,et al."Design and synthesis of new tetrandrine derivatives and their antitumor activities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18.10(2016):966-975. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。