KCNQ potassium channels in sensory system and neural circuits
文献类型：期刊论文
| 作者 | Wang, Jing-jing; Li, Yang
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2016-01 |
| 卷号 | 37期号:1页码:25-33 |
| 关键词 | KCNQ channels M channels neural circuits channelopathy epilepsy neuropathic pain deafness mental illness |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.131 |
| 文献子类 | Review |
| 英文摘要 | M channels, an important regulator of neural excitability, are composed of four subunits of the Kv7 (KCNQ) K+ channel family. M channels were named as such because their activity was suppressed by stimulation of muscarinic acetylcholine receptors. These channels are of particular interest because they are activated at the subthreshold membrane potentials. Furthermore, neural KCNQ channels are drug targets for the treatments of epilepsy and a variety of neurological disorders, including chronic and neuropathic pain, deafness, and mental illness. This review will update readers on the roles of KCNQ channels in the sensory system and neural circuits as well as discuss their respective mechanisms and the implications for physiology and medicine. We will also consider future perspectives and the development of additional pharmacological models, such as seizure, stroke, pain and mental illness, which work in combination with drug-design targeting of KCNQ channels. These models will hopefully deepen our understanding of KCNQ channels and provide general therapeutic prospects of related channelopathies. |
| WOS关键词 | RETINAL-PIGMENT EPITHELIUM ; LONG-TERM POTENTIATION ; FAMILIAL NEONATAL CONVULSIONS ; ACCESSORY OLFACTORY-BULB ; RAT HIPPOCAMPAL SLICES ; OUTER HAIR-CELLS ; K+ CHANNELS ; DOMINANT DEAFNESS ; LANGE-NIELSEN ; HEARING-LOSS |
| 资助项目 | National Natural Science Foundation of China[31128009] ; National Natural Science Foundation of China[31171011] ; National Natural Science Foundation of China[31171066] ; National Natural Science Foundation of China[91413122] ; Ministry of Science and Technology of China[2013CB910601] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5613573 |
| WOS记录号 | WOS:000367514700005 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276268]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Li, Yang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing-jing,Li, Yang. KCNQ potassium channels in sensory system and neural circuits[J]. ACTA PHARMACOLOGICA SINICA,2016,37(1):25-33. |
| APA | Wang, Jing-jing,&Li, Yang.(2016).KCNQ potassium channels in sensory system and neural circuits.ACTA PHARMACOLOGICA SINICA,37(1),25-33. |
| MLA | Wang, Jing-jing,et al."KCNQ potassium channels in sensory system and neural circuits".ACTA PHARMACOLOGICA SINICA 37.1(2016):25-33. |
入库方式： OAI收割
来源：上海药物研究所
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