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Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression

文献类型：期刊论文

作者Zhou, Rui1; Lu, Yi1; Han, Yong1; Li, Xia1; Lou, Huifang1; Zhu, Liya1; Zhen, Xuechu2,3; Duan, Shumin1
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
出版日期2015-12-03
卷号63页码:110-118
关键词Cathepsin D Congenital Neuronal Ceroid-lipofuscinosis Bipolar Disorder Animal Disease Model
ISSN号0278-5846
DOI10.1016/j.pnpbp.2015.06.007
文献子类Article
英文摘要Mutations in cathepsin D (CTSD), an aspartic protease in the endosomal-lysosomal system, underlie congenital neuronal ceroid-lipofuscinosis (cNCL, also known as CLN10), a devastating neurodegenerative disease. CLN10 patients die within the first few days of life, and in the few patients who live into adulthood psychopathological symptoms have not been reported. Extensive neuropathology and altered neurotransmission have been reported in CTSD-deficientmice; however signs of neuropsychiatric behavior in these mice are not well characterized due to the severe movement disorder and premature death of the animal. In the present study, we show that heterozygous CTSD-deficient (CTSD HET) mice display an overall behavioral profile that is similar to human mania, including hyperlocomotion, D-amphetamine-induced hyperactivity, sleep-disturbance, and reduced anxiety-like behavior. However, under stressful conditions CTSD HET micemanifest depressive-like behavior, including anhedonia, behavioral despair, and enhanced learned helplessness. Chronic administration of lithium chloride or valproic acid, two clinically effective mood stabilizers, reverses the majority of these behavioral abnormalities. In addition, CTSD HET mice display stress-induced hypersecretion of corticosterone. These findings suggest an important role for CTSD in the regulation of mood stabilization. (C) 2015 Elsevier Inc. All rights reserved.
WOS关键词NEURONAL CEROID-LIPOFUSCINOSIS ; BIPOLAR DISORDER ; PSYCHIATRIC-SYMPTOMS ; SLEEP DISTURBANCES ; BATTEN-DISEASE ; RISK-TAKING ; MOUSE ; NCL ; PATHOLOGY ; ANXIETY
资助项目Major State Basic Research Program of China[2011CB504400] ; National Natural Science Foundation of China[31190060] ; National Natural Science Foundation of China[31490590] ; National Natural Science Foundation of China[91232000] ; National Natural Science Foundation of China[81221003] ; National Natural Science Foundation of China[31471308] ; National Key Technology R&D Program of the ministry of Science and Technology of China[2012BAI01B08] ; Program for Introducing Talents in Discipline to Universities[B13026] ; Fundamental Research Funds for the Central Universities[2014FZA7007]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:000358008000015
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276288]  
专题药理学第二研究室
通讯作者Duan, Shumin
作者单位1.Zhejiang Univ, Sch Med, Dept Neurobiol, Key Lab Med Neurobiol,Key Lab Neurobiol,Minist Hl, Hangzhou 310058, Zhejiang, Peoples R China;
2.Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Zhou, Rui,Lu, Yi,Han, Yong,et al. Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2015,63:110-118.
APA Zhou, Rui.,Lu, Yi.,Han, Yong.,Li, Xia.,Lou, Huifang.,...&Duan, Shumin.(2015).Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,63,110-118.
MLA Zhou, Rui,et al."Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 63(2015):110-118.

入库方式： OAI收割

来源：上海药物研究所

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