Antagonism of kappa opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence
文献类型：期刊论文
| 作者 | Zan, Gui-Ying2,3; Wang, Qian1; Wang, Yu-Jun2,3 ; Liu, Yao4; Hang, Ai5; Shu, Xiao-Hong1; Liu, Jing-Gen2,3
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| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2015-09-15 |
| 卷号 | 291页码:334-341 |
| 关键词 | kappa Opioid receptor Prodynorphin Morphine withdrawal Nucleus accumbens Depression |
| ISSN号 | 0166-4328 |
| DOI | 10.1016/j.bbr.2015.05.053 |
| 文献子类 | Article |
| 英文摘要 | The association between morphine withdrawal and depressive-like symptoms is well documented, however, the role of dynorphin/kappa opioid receptor system and the underlying neural substrates have not been fully understood. In the present study, we found that four weeks morphine abstinence after a chronic escalating morphine regimen significantly induced depressive-like behaviors in mice. Prodynorphin mRNA and protein levels were increased in the nucleus accumbens (NAc) after four weeks of morphine withdrawal. Local injection of kappa opioid receptor antagonist nor-Binaltorphimine (norBNI) in the NAc significantly blocked the expression of depressive-like behaviors without influencing general locomotor activity. Thus, the present study extends previous findings by showing that prolonged morphine withdrawal-induced depressive-like behaviors are regulated by dynorphin/kappa opioid receptor system, and shed light on the kappa opioid receptor antagonists as potential therapeutic agents for the treatment of depressive-like behaviors induced by opiate withdrawal. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | FORCED SWIM TEST ; ELEMENT-BINDING PROTEIN ; LONG-TERM CHANGES ; ANHEDONIA HYPOTHESIS ; OPIATE WITHDRAWAL ; PLACE PREFERENCE ; COCAINE-SEEKING ; GENE-EXPRESSION ; STRESS ; RATS |
| 资助项目 | Ministry of Science and Technology of China[2013CB835100] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; Committee of Science and Technology of Shanghai[13JC140680] |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000358454800041 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276397]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Liu, Jing-Gen |
| 作者单位 | 1.Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China; 2.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China; 5.China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zan, Gui-Ying,Wang, Qian,Wang, Yu-Jun,et al. Antagonism of kappa opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence[J]. BEHAVIOURAL BRAIN RESEARCH,2015,291:334-341. |
| APA | Zan, Gui-Ying.,Wang, Qian.,Wang, Yu-Jun.,Liu, Yao.,Hang, Ai.,...&Liu, Jing-Gen.(2015).Antagonism of kappa opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence.BEHAVIOURAL BRAIN RESEARCH,291,334-341. |
| MLA | Zan, Gui-Ying,et al."Antagonism of kappa opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence".BEHAVIOURAL BRAIN RESEARCH 291(2015):334-341. |
入库方式： OAI收割
来源：上海药物研究所
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