Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants
文献类型：期刊论文
| 作者 | Guo, Fei; Zhang, Qi; Zhang, Bing; Fu, Zhiwen; Wu, Bin; Huang, Chenggang ; Li, Yang
|
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2014-11 |
| 卷号 | 40期号:10页码:3538-3547 |
| 关键词 | brain-derived neurotrophic factor medial prefrontal cortex mouse ventral tegmental area |
| ISSN号 | 0953-816X |
| DOI | 10.1111/ejn.12725 |
| 文献子类 | Article |
| 英文摘要 | Major depressive disorder (MDD) is one of the leading causes of morbidity worldwide. Several antidepressants have been widely prescribed to treat patients with MDD. However, neuronal changes in brain function remain poorly understood. Based on the standard chronic mild stress (CMS) model of depression in mice, we investigated the neuronal mechanisms of the classic antidepressant, fluoxetine, and a new compound (termed YY-23 in this study) derived from furostanol saponin. The results showed that both fluoxetine and YY-23 normalized CMS-induced depressive-like behaviors. YY-23 caused antidepressant-like behaviors with a faster action than fluoxetine. In terms of in vivo neuronal activities, a CMS-induced decrease in spontaneous firing in burst of medial prefrontal cortex pyramidal neurons rather than ventral tegmental area (VTA) was reversed by the chronic administration of fluoxetine and YY-23. We also found that CMS-induced deficits in the expression of prefrontal brain-derived neurotrophic factor (BDNF) were also restored by chronically administering YY-23 and fluoxetine. In addition, chronic administration of fluoxetine rather than YY-23 resulted in an improvement of antidepressive-like behavior and a change of burst firing of VTA in control-housed animals, indicating that the pharmacological effects of YY-23 were specific to CMS-treated animals. Together, these data suggest that the burst-firing patterns of pyramidal cells may be a neural biomarker of depressive-like mice and antidepressant action. Furthermore, synaptic transmission and BDNF may contribute to the rapid antidepressant-like effects on depression. |
| WOS关键词 | CHRONIC MILD STRESS ; MIDBRAIN DOPAMINERGIC-NEURONS ; BRAIN REWARD CIRCUIT ; SUCROSE CONSUMPTION ; MOOD DISORDERS ; ANIMAL-MODELS ; SEROTONIN ; VALIDITY ; DISEASE ; RATS |
| 资助项目 | National Natural Science Foundation[31200771] ; National Natural Science Foundation[81030065] ; National Natural Science Foundation[81274055] ; National Natural Science Foundation[3112800901] ; National Natural Science Foundation[3117101101] ; Ministry of Science and Technology[2013CB91060101] ; Chinese Academy of Sciences Foundation[2320103112110201] ; Chinese Academy of Sciences Foundation[5512345601] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000345302400011 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276851]  |
| 专题 | 药理学第二研究室 上海中药现代化研究中心 |
| 通讯作者 | Guo, Fei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Fei,Zhang, Qi,Zhang, Bing,et al. Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2014,40(10):3538-3547. |
| APA | Guo, Fei.,Zhang, Qi.,Zhang, Bing.,Fu, Zhiwen.,Wu, Bin.,...&Li, Yang.(2014).Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants.EUROPEAN JOURNAL OF NEUROSCIENCE,40(10),3538-3547. |
| MLA | Guo, Fei,et al."Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants".EUROPEAN JOURNAL OF NEUROSCIENCE 40.10(2014):3538-3547. |
入库方式： OAI收割
来源：上海药物研究所
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