H-1, C-13 and N-15 backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25
文献类型：期刊论文
| 作者 | Shi, Li; Wen, Yi; Zhang, Naixia
|
| 刊名 | BIOMOLECULAR NMR ASSIGNMENTS
 |
| 出版日期 | 2014-10 |
| 卷号 | 8期号:2页码:255-258 |
| 关键词 | Deubiquitinase USP25 Ubiquitin-binding domain Cross-regulation NMR |
| ISSN号 | 1874-2718 |
| DOI | 10.1007/s12104-013-9495-1 |
| 文献子类 | Article |
| 英文摘要 | Ubiquitin Specific Protease 25 (USP25), a member of the deubiquitinase family, is involved in several disease-related signal pathways including myogenesis, immunity and protein degradation. It specially catalyzes the hydrolysis of the K48-linked and K63-linked polyubiquitin chains. USP25 contains one ubiquitin-associated domain and two ubiquitin-interacting motifs (UIMs) in its N-terminal region, which interact with ubiquitin and play a role in substrate recognition. Besides, it has been shown that the catalysis activity of USP25 is either impaired by sumoylation or enhanced by ubiquitination within its UIM. To elucidate the structural basis of the cross-regulation of USP25 function by non-covalent binding and covalent modifications of ubiquitin and SUMO2/3, a systematic structural biology study of USP25 is required. Here, we report the H-1, C-13 and N-15 backbone and side-chain resonance assignments of the N-terminal ubiquitin binding domains (UBDs) of USP25 with BMRB accession number of 19111, which is the first step of the systematic structural biology study of the enzyme. |
| WOS关键词 | DEUBIQUITINATING ENZYMES ; PROTEASE USP25 ; EMERGING ROLES ; CANCER ; PROTEINS ; SYSTEM |
| 资助项目 | National Key Basic Research Program of China[2013CB910900] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Biophysics ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000342080900008 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276889]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Zhang, Naixia |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Li,Wen, Yi,Zhang, Naixia. H-1, C-13 and N-15 backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25[J]. BIOMOLECULAR NMR ASSIGNMENTS,2014,8(2):255-258. |
| APA | Shi, Li,Wen, Yi,&Zhang, Naixia.(2014).H-1, C-13 and N-15 backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25.BIOMOLECULAR NMR ASSIGNMENTS,8(2),255-258. |
| MLA | Shi, Li,et al."H-1, C-13 and N-15 backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25".BIOMOLECULAR NMR ASSIGNMENTS 8.2(2014):255-258. |
入库方式： OAI收割
来源：上海药物研究所
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