Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum
文献类型：期刊论文
| 作者 | Zhou, Zhen-Fang1; Kong, Ling-Yi4; Kurtan, Tibor3; Liu, Hai-Li1; Mandi, Attila3; Li, Jia1 ; Gu, Yu-Cheng2; Guo, Yue-Wei1
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| 刊名 | PLANTA MEDICA
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| 出版日期 | 2014-07 |
| 卷号 | 80期号:11页码:949-954 |
| 关键词 | Meliaceae Xylocarpus granatum phragmalin orthoesters configuration determination biological activity |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0034-1382840 |
| 文献子类 | Article |
| 英文摘要 | Four new 8,9,30-phragmalin orthoesters (1-4), along with six related known compounds, namely xyloccensins O-S (5-9) and V (10), were isolated and characterized from the twigs and leaves of the Chinese mangrove Xylocarpus granatum. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and by comparison with those of related known compounds in the literature. The absolute configuration of xyloccensin Q(7) was revised as its enantiomer by X-ray diffraction analysis employing graphite monochromated Cu K alpha radiation (lambda = 1.54178 angstrom) with a Flack parameter of -0.04 and was further secured by a time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Consequently, the absolute configurations of xyloccensins O (5), P (6), R (8), S (9), and V (10) were all corrected as their corresponding enantiomers, respectively. Xyloccensin S (9) exhibited inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of type II diabetes and obesity, with an IC50 value of 8.72 mu g/mL. |
| WOS关键词 | KRISHNA MANGROVE ; LIMONOIDS ; SEEDS ; XYLOMEXICANINS |
| 资助项目 | National Marine '863' Project[2011AA09070102] ; National Marine '863' Project[2013AA092902] ; Natural Science Foundation of China[81273430] ; SKLDR/SIMM Projects[SIMM 1203ZZ-03] ; Syngenta-SIMM-PhD Studentship Project[00000000] ; SKLNM/CPU project[SKLNMKF 201412] ; Hungarian National Research Foundation[OTKA K105871] ; Hungarian National Research Foundation[K81701] ; National Information Infrastructure Development Institute[NIIFI 10038] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000340577700014 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276994]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Syngenta Jealotts Hill Int Res Ctr, Bracknell, Berks, England 3.Univ Debrecen, Dept Organ Chem, H-4012 Debrecen, Hungary; 4.China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Zhen-Fang,Kong, Ling-Yi,Kurtan, Tibor,et al. Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum[J]. PLANTA MEDICA,2014,80(11):949-954. |
| APA | Zhou, Zhen-Fang.,Kong, Ling-Yi.,Kurtan, Tibor.,Liu, Hai-Li.,Mandi, Attila.,...&Guo, Yue-Wei.(2014).Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum.PLANTA MEDICA,80(11),949-954. |
| MLA | Zhou, Zhen-Fang,et al."Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum".PLANTA MEDICA 80.11(2014):949-954. |
入库方式： OAI收割
来源：上海药物研究所
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