Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis
文献类型：期刊论文
| 作者 | Liu, Xia2 ; Zhong, Fang1; Tang, Xu-long2; Lian, Fu-lin2; Zhou, Qiao1; Guo, Shan-mai1; Liu, Jia-fu3; Sun, Peng2; Hao, Xu1; Lu, Ying1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2014-05 |
| 卷号 | 35期号:5页码:697-706 |
| 关键词 | Cordyceps sinensis chronic kidney disease liver injury heart injury metabolomics nuclear magnetic resonance traditional Chinese medicine |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2013.186 |
| 文献子类 | Article |
| 英文摘要 | Aim: To test the hypothesis that the traditional Chinese medicine Cordyceps sinensis could improve the metabolic function of extrarenal organs to achieve its anti-chronic kidney disease (CKD) effects. Methods: Male SD rats were divided into CKD rats (with 5/6-nephrectomy), CKD rats treated with Cordyceps sinensis (4 mg.kg(-1).d(-1), po), and sham-operated rats. After an 8-week treatment, metabolites were extracted from the hearts and livers of the rats, and then subjected to H-1-NMR-based metabolomic analysis. Results: Oxidative stress, energy metabolism, amino acid and protein metabolism and choline metabolism were considered as links between CKD and extrarenal organ dysfunction. Within the experimental period of 8 weeks, the metabolic disorders in the liver were more pronounced than in the heart, suggesting that CKD-related extrarenal organ dysfunctions occurred sequentially rather than simultaneously. Oral administration of Cordyceps sinensis exerted statistically significant rescue effects on the liver and heart by reversely regulating levels of those metabolites that are typically perturbed in CKD. Conclusion: Oral administration of Cordyceps sinensis significantly attenuates the liver and heart injuries in CKD rats. The H-1 NMR-based metabolomic approach has provided a systematic view for understanding of CKD and the drug treatment, which can also be used to elucidate the mechanisms of action of other traditional Chinese medicines. |
| WOS关键词 | CHRONIC-RENAL-FAILURE ; UPLC Q-TOF/HSMS/MSE ; OXIDATIVE STRESS ; URINARY METABONOMICS ; H-1-NMR SPECTROSCOPY ; HEPATIC GLUTATHIONE ; PORIA-COCOS ; Q-TOF/MS ; TAURINE ; TISSUE |
| 资助项目 | National Natural Science Foundation of China[30900662] ; Shanghai Foundation for Development of Science and Technology[08411965600] ; "100 Talents Program" of the Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5142660 |
| WOS记录号 | WOS:000335447000014 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277102]  |
| 专题 | 分析化学研究室 药物安全性评价中心 |
| 通讯作者 | Wang, Wei-ming |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Nephrol, Shanghai 200025, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, Shanghai 201203, Peoples R China; 3.Blood Ctr Wisconsin, Blood Res Inst, Milwaukee, WI 53226 USA |
| 推荐引用方式 GB/T 7714 | Liu, Xia,Zhong, Fang,Tang, Xu-long,et al. Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis[J]. ACTA PHARMACOLOGICA SINICA,2014,35(5):697-706. |
| APA | Liu, Xia.,Zhong, Fang.,Tang, Xu-long.,Lian, Fu-lin.,Zhou, Qiao.,...&Zhang, Nai-xia.(2014).Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis.ACTA PHARMACOLOGICA SINICA,35(5),697-706. |
| MLA | Liu, Xia,et al."Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis".ACTA PHARMACOLOGICA SINICA 35.5(2014):697-706. |
入库方式： OAI收割
来源：上海药物研究所
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