Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness
文献类型：期刊论文
| 作者 | Zhang, Lei; Zheng, Mingyue ; Zhao, Fei; Zhai, Yun; Liu, Hong
|
| 刊名 | ACS COMBINATORIAL SCIENCE
 |
| 出版日期 | 2014-04 |
| 卷号 | 16期号:4页码:184-191 |
| 关键词 | indole diversity-oriented synthesis drug-like privileged structure microwave |
| ISSN号 | 2156-8952 |
| DOI | 10.1021/co4001309 |
| 文献子类 | Article |
| 英文摘要 | A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave-assisted cyclizations in branched pathways. Cheminformatic analysis confirmed that the library exhibited a high degree of structural diversity and good drug-likeness. |
| WOS关键词 | POLYHETEROCYCLIC BENZOPYRAN LIBRARY ; ORIENTED SYNTHESIS PATHWAY ; FACILE CONSTRUCTION ; CHEMICAL SPACE ; CORE SKELETONS ; UGI-ADDUCTS ; SINGLE SET ; DISCOVERY ; HETEROCYCLES ; INDOLE |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000334571500006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277131]  |
| 专题 | 药物化学研究室 药理学第二研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Zheng, Mingyue,Zhao, Fei,et al. Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness[J]. ACS COMBINATORIAL SCIENCE,2014,16(4):184-191. |
| APA | Zhang, Lei,Zheng, Mingyue,Zhao, Fei,Zhai, Yun,&Liu, Hong.(2014).Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness.ACS COMBINATORIAL SCIENCE,16(4),184-191. |
| MLA | Zhang, Lei,et al."Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness".ACS COMBINATORIAL SCIENCE 16.4(2014):184-191. |
入库方式： OAI收割
来源：上海药物研究所
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