Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response
文献类型：期刊论文
| 作者 | Geng, Lei-Yu1,3; Ye, Dong-Qing1,3; Shi, Yan-Yan2; Xu, Zhi1,3; Pu, Meng-Jia1,3; Li, Zan-Yuan4; Li, Xiao-Li1,3; Li, Yang4 ; Zhang, Zhi-Jun1,3
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| 刊名 | CNS NEUROSCIENCE & THERAPEUTICS
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| 出版日期 | 2014-03 |
| 卷号 | 20期号:3页码:237-243 |
| 关键词 | HPA CRHR1 Antidepressant response Environmental factors |
| ISSN号 | 1755-5930 |
| DOI | 10.1111/cns.12201 |
| 文献子类 | Article |
| 英文摘要 | Aims To investigate the role of genetic polymorphisms in candidate genes associated with the HPA axis and their interactions with environmental stressors in antidepressant response. Methods The remission of depressive symptoms after 8weeks of antidepressant treatment was tested against 21 single nucleotide polymorphisms (SNPs) in five candidate genes associated with the HPA axis in a Chinese Han sample suffering from unipolar depression (n=273). Any history of childhood trauma and recent negative life events were measured using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) (n=206) and the Life Event Scale (48 item, LES) (n=207), respectively. Reporter gene assays were used to evaluate the possible effects of the most significant SNP on gene expression. Results A functional polymorphism at 3 ' UTR of the corticotropin-releasing hormone receptor 1 (CRHR1) gene (rs28364032) and three haplotypes containing it showed significant relationships with antidepressant remission. Further laboratory-based genomic studies showed that the G-to-A change of rs28364032 resulted in a 10-12% decrease in the intensity of luciferase activity. However, we failed to find association of environments and their interaction with HPA system-related genes with antidepressant remission. Conclusions Our results support a definite role for CRHR1 in the pharmacogenetics of antidepressant drugs. This may contribute to interpatient differences in their responses to antidepressant drugs. |
| WOS关键词 | MICRORNA TARGET SITES ; ADULT DEPRESSION ; MAJOR DEPRESSION ; LIFE EVENTS ; LINKING POLYMORPHISMS ; POLYMIRTS DATABASE ; CHILDHOOD TRAUMA ; COMPLEX TRAITS ; STRESS ; VARIANTS |
| 资助项目 | National Nature Science Foundation of China for the Excellent Young Scientist[30825014] ; National Major Science and Technology Program of China[2012ZX09506-001-009] ; National Natural Science Foundation of China for International (Regional) Cooperation and Exchange Programs[81061120529] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000331540800006 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277176]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Zhang, Zhi-Jun |
| 作者单位 | 1.Southeast Univ, Affiliated ZhongDa Hosp, Dept Neurol, Neuropsychiat Inst, Nanjing 210009, Jiangsu, Peoples R China; 2.First Hosp Nanjing, Dept Neurol, Nanjing, Jiangsu, Peoples R China; 3.Southeast Univ, Sch Med, Nanjing 210009, Jiangsu, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Lei-Yu,Ye, Dong-Qing,Shi, Yan-Yan,et al. Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response[J]. CNS NEUROSCIENCE & THERAPEUTICS,2014,20(3):237-243. |
| APA | Geng, Lei-Yu.,Ye, Dong-Qing.,Shi, Yan-Yan.,Xu, Zhi.,Pu, Meng-Jia.,...&Zhang, Zhi-Jun.(2014).Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response.CNS NEUROSCIENCE & THERAPEUTICS,20(3),237-243. |
| MLA | Geng, Lei-Yu,et al."Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response".CNS NEUROSCIENCE & THERAPEUTICS 20.3(2014):237-243. |
入库方式： OAI收割
来源：上海药物研究所
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