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Xanthan gum inhibits cartilage degradation by down-regulating matrix metalloproteinase-1 and -3 expressions in experimental osteoarthritis

文献类型：期刊论文

作者Han, Guan-Ying1,2,3; Mei, Xi-Fan2; Ling, Pei-Xue3; Guo, Yue-Wei1; Zhu, Xi-Qiang3; Shao, Hua-Rong3; Liu, Fei3; Zhang, Tian-Min3
刊名JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
出版日期2014-03
卷号29期号:2页码:180-189
关键词apoptosis osteoarthritis tissue inhibitors of metalloproteinase-1 protein expression matrix metalloproteinase Xanthan gum matrix metalloproteinase-3 protein expression chondrocyte apoptosis matrix metalloproteinase-1 protein expression
ISSN号0883-9115
DOI10.1177/0883911514521916
文献子类Article
英文摘要We previously reported that intra-articular injection of xanthan gum protected the joint cartilage and reduced osteoarthritis progression. In this study, the effects of xanthan gum on chondrocytes apoptosis were evaluated using the labeling assay, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, to determine the protein expression of matrix metalloproteinase-1, 3, and tissue inhibitors of metalloproteinase-1 using immunohistochemistry and Western blot assay in cartilage of papain-induced rabbit osteoarthritis model. Compared to the negative control group, intra-articular injection of xanthan gum, once every 2 weeks for 5 weeks significantly inhibited chondrocytes apoptosis and matrix metalloproteinase-1 and -3 protein expression levels and also enhanced the tissue inhibitors of metalloproteinase-1 production in cartilage. No significant differences between the xanthan gum-treated group and the sodium hyaluronate-treated group (intra-articular injection of sodium hyaluronate only once a week for 5 weeks) were observed.
WOS关键词ARTICULAR-CARTILAGE ; CHONDROCYTE APOPTOSIS ; GENE-EXPRESSION ; CELL-DEATH
资助项目National Natural Science Foundation of China[81302681] ; Liaoning Province Natural Science Foundation of China[2013022051]
WOS研究方向Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science
语种英语
WOS记录号WOS:000331618800007
出版者SAGE PUBLICATIONS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277178]  
专题天然药物化学研究室
通讯作者Ling, Pei-Xue
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou, Peoples R China;
3.Inst Biopharmaceut Shandong Prov, Postdoctoral Sci Res Workstn, Jinan 250101, Peoples R China;
推荐引用方式
GB/T 7714		 Han, Guan-Ying,Mei, Xi-Fan,Ling, Pei-Xue,et al. Xanthan gum inhibits cartilage degradation by down-regulating matrix metalloproteinase-1 and -3 expressions in experimental osteoarthritis[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2014,29(2):180-189.
APA Han, Guan-Ying.,Mei, Xi-Fan.,Ling, Pei-Xue.,Guo, Yue-Wei.,Zhu, Xi-Qiang.,...&Zhang, Tian-Min.(2014).Xanthan gum inhibits cartilage degradation by down-regulating matrix metalloproteinase-1 and -3 expressions in experimental osteoarthritis.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,29(2),180-189.
MLA Han, Guan-Ying,et al."Xanthan gum inhibits cartilage degradation by down-regulating matrix metalloproteinase-1 and -3 expressions in experimental osteoarthritis".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 29.2(2014):180-189.

入库方式： OAI收割

来源：上海药物研究所

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