Recent technological developments in proteomics shed new light on translational research on diabetic microangiopathy
文献类型：期刊论文
| 作者 | Ma, Yuhang2; Yang, Cheng3; Tao, Yimin1,3; Zhou, Hu1,3 ; Wang, Yufan2
|
| 刊名 | FEBS JOURNAL
 |
| 出版日期 | 2013-11 |
| 卷号 | 280期号:22页码:5668-5681 |
| 关键词 | clinical application diabetic nephropathy diabetic retinopathy proteomics translational research |
| ISSN号 | 1742-464X |
| DOI | 10.1111/febs.12369 |
| 文献子类 | Review |
| 英文摘要 | Diabetic microangiopathy has become a heavy social burden worldwide, but at present it is still difficult to predict and diagnose this ailment at an early stage. Various proteomics approaches have been applied to the pathophysiological study of diabetic microangiopathy. Conventional proteomics methods, including gel-based methods, exhibit limited sensitivity and robustness and have typically been used in high- or middle-abundance biomarker discovery. Clinical samples from patients with diabetic microangiopathy, such as biopsy samples, are minute in size. Therefore sample preparation, quantitative labelling and mass spectrometry technologies need to be optimized for low-abundance protein detection, multiple-sample processing and precision quantitation. In this review, we briefly introduce the recent technological developments in proteomics methods and summarize current proteomics-based, translational research on diabetic microangiopathy. Recent technological developments in proteomics tools may shed new light on the pathogenesis of diabetic microangiopathy and biomarkers and therapeutic targets related to this condition. |
| WOS关键词 | SEED PROANTHOCYANIDIN EXTRACTS ; IMAGING MASS-SPECTROMETRY ; PARAFFIN-EMBEDDED TISSUE ; GEL-ELECTROPHORESIS ; QUANTITATIVE PROTEOMICS ; BIOMARKER DISCOVERY ; URINARY PROTEOMICS ; ALBUMIN EXCRETION ; VITREOUS FLUID ; NEPHROPATHY |
| 资助项目 | Natural Science Foundation of Shanghai[10ZR1424100] ; Chinese Academy of Sciences[YG2012106] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000327130900010 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277395]  |
| 专题 | 分析化学研究室 药物安全性评价中心 |
| 通讯作者 | Wang, Yufan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Endocrinol & Metab, Shanghai 200080, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ma, Yuhang,Yang, Cheng,Tao, Yimin,et al. Recent technological developments in proteomics shed new light on translational research on diabetic microangiopathy[J]. FEBS JOURNAL,2013,280(22):5668-5681. |
| APA | Ma, Yuhang,Yang, Cheng,Tao, Yimin,Zhou, Hu,&Wang, Yufan.(2013).Recent technological developments in proteomics shed new light on translational research on diabetic microangiopathy.FEBS JOURNAL,280(22),5668-5681. |
| MLA | Ma, Yuhang,et al."Recent technological developments in proteomics shed new light on translational research on diabetic microangiopathy".FEBS JOURNAL 280.22(2013):5668-5681. |
入库方式： OAI收割
来源：上海药物研究所
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