Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora
文献类型：期刊论文
| 作者 | Wang, Hongmin2; Zhao, Weimin2 ; Choomuenwai, Vanida1; Andrews, Katherine T.1; Quinn, Ronald J.1; Feng, Yunjiang1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 23期号:21页码:5915-5918 |
| 关键词 | Traditional Chinese medicine Antimalarial Picrorhiza scrophulariiflora |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2013.08.077 |
| 文献子类 | Article |
| 英文摘要 | An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 mu M. This compound accounted for similar to 95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | BIOLOGICAL EVALUATION ; GLYCOSIDES ; MALARIA ; AGENTS |
| 资助项目 | Australian Research Council (ARC)[LE0668477] ; Australian Research Council (ARC)[LE0237908] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000325483000033 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277409]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Quinn, Ronald J. |
| 作者单位 | 1.Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Hongmin,Zhao, Weimin,Choomuenwai, Vanida,et al. Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(21):5915-5918. |
| APA | Wang, Hongmin,Zhao, Weimin,Choomuenwai, Vanida,Andrews, Katherine T.,Quinn, Ronald J.,&Feng, Yunjiang.(2013).Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(21),5915-5918. |
| MLA | Wang, Hongmin,et al."Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.21(2013):5915-5918. |
入库方式： OAI收割
来源：上海药物研究所
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