Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum
文献类型：期刊论文
| 作者 | Liu, Shuangzhu; Chen, Zhenhua; Wu, Jian; Wang, Luoyi; Wang, Hongmin; Zhao, Weimin
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2013-09 |
| 卷号 | 93页码:144-153 |
| 关键词 | Cynanchum auriculatum Asclepiadaceae Pregnane glycoside Appetite suppressant |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2013.03.010 |
| 文献子类 | Article |
| 英文摘要 | In the search for plant alternatives to Hoodia gordonii containing P57, a pregnane glycoside with potential appetite suppressant effect, the roots of Cynanchum auriculatum were investigated. As a result, 15 pregnane glycosides including nine never previously reported were isolated. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. Appetite suppressant effect and body weight loss were observed when tested with the most abundant pregnane glycoside, wilfoside K1N, in an in vivo test with rats. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | C-21 STEROIDAL GLYCOSIDES ; OPTICALLY ISOMERIC SUGARS ; ROYLE-EX-WIGHT ; HOODIA-GORDONII ; CONSTITUENTS ; EXTRACT ; OBESITY ; CHAIN ; PLANT ; PAIR |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; Natural Science Foundation of China[81273399] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000323630000015 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277487]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Zhao, Weimin |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shuangzhu,Chen, Zhenhua,Wu, Jian,et al. Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum[J]. PHYTOCHEMISTRY,2013,93:144-153. |
| APA | Liu, Shuangzhu,Chen, Zhenhua,Wu, Jian,Wang, Luoyi,Wang, Hongmin,&Zhao, Weimin.(2013).Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum.PHYTOCHEMISTRY,93,144-153. |
| MLA | Liu, Shuangzhu,et al."Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum".PHYTOCHEMISTRY 93(2013):144-153. |
入库方式： OAI收割
来源：上海药物研究所
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