Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats
文献类型：期刊论文
| 作者 | Kang, Shuo1; Ling, Qing-lan1; Liu, Wen-tao2; Lu, Bin1; Liu, Yao1; He, Lin2; Liu, Jing-gen1
|
| 刊名 | NEUROBIOLOGY OF LEARNING AND MEMORY
 |
| 出版日期 | 2013-07 |
| 卷号 | 103页码:3-10 |
| 关键词 | RhoA Neuroplasticity Aging Working memory Dorsal Striatum |
| ISSN号 | 1074-7427 |
| DOI | 10.1016/j.nlm.2013.03.005 |
| 文献子类 | Article |
| 英文摘要 | The effect of aging on learning and memory has been intensively studied. However, the mechanisms underlying impairment of memory functions at middle age remains inexplicit. To address this question, we assessed the spatial working memory and long-term memory of middle-aged (16-18 months) rats with delayed alternation in T-maze and water maze task respectively. We observed a significant impairment of spatial working memory in middle-aged rats in delayed alternation in T-Maze task, while long-term spatial memory remained unchanged. To further explore possible mechanisms underlying this age-associated impairment of spatial working memory, we examined the activity of RhoA in the prefrontal cortex, dorsal hippocampus, dorsal striatum and sensorimotor cortex. We found that middle-aged rats showed a significant decrease in RhoA activity in dorsal striatum but not in other regions examined, while the protein level remained unchanged compared to the young rats (2-3 months). Moreover, we found that microinfusion of Y-27632, a specific inhibitor of the ROCK that is a downstream effector of RhoA, into dorsal striatum of young rats also impaired their working memory tested in delayed alternation in T Maze task. These results suggest that RhoA activity in dorsal striatum may play a role in mediating spatial working memory. (C) 2013 Elsevier Inc. All rights reserved. |
| WOS关键词 | LONG-TERM POTENTIATION ; DELAYED ALTERNATION PERFORMANCE ; SYNAPTIC PLASTICITY ; SPATIAL MEMORY ; ENVIRONMENTAL ENRICHMENT ; GENE-EXPRESSION ; PROTEIN-KINASE ; IN-VIVO ; DEFICITS ; DECLINE |
| 资助项目 | Ministry of Science and Technology of China[2009CB522005] ; Foundation of National Natural Science of China[81130087] ; Foundation of National Natural Science of China[81001424] |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Psychology |
| 语种 | 英语 |
| WOS记录号 | WOS:000320293400002 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277571]  |
| 专题 | 药理学第二研究室 |
| 通讯作者 | Liu, Jing-gen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Neuropharmacol, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Dept Pharm, Nanjing, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kang, Shuo,Ling, Qing-lan,Liu, Wen-tao,et al. Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2013,103:3-10. |
| APA | Kang, Shuo.,Ling, Qing-lan.,Liu, Wen-tao.,Lu, Bin.,Liu, Yao.,...&Liu, Jing-gen.(2013).Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats.NEUROBIOLOGY OF LEARNING AND MEMORY,103,3-10. |
| MLA | Kang, Shuo,et al."Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats".NEUROBIOLOGY OF LEARNING AND MEMORY 103(2013):3-10. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。