Prion protein oligomer and its neurotoxicity
文献类型：期刊论文
| 作者 | Huang, Pei3; Lian, Fulin1; Wen, Yi1; Guo, Chenyun2; Lin, Donghai2 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2013-06 |
| 卷号 | 45期号:6页码:442-451 |
| 关键词 | prion oligomer neurotoxicity transmissible spongiform encephalopathies |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmt037 |
| 文献子类 | Review |
| 英文摘要 | The prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. According to the protein only hypothesis, the key molecular event in the pathogenesis of prion disease is the conformational conversion of the host-derived cellular prion protein (PrPC) into a misfolded form (scrapie PrP, PrPSc). Increasing evidence has shown that the most infectious factor is the smaller subfibrillar oligomers formed by prion proteins. Both the prion oligomer and PrPSc are rich in -sheet structure and resistant to the proteolysis of proteinase K. The prion oligomer is soluble in physiologic environments whereas PrPSc is insoluble. Various prion oligomers are formed in different conditions. Prion oligomers exhibited more neurotoxicity both in vitro and in vivo than the fibrillar forms of PrPSc, implying that prion oligomers could be potential drug targets for attacking prion diseases. In this article, we describe recent experimental evidence regarding prion oligomers, with a special focus on prion oligomer formation and its neurotoxicity. |
| WOS关键词 | MOLTEN GLOBULE INTERMEDIATE ; NUCLEAR-MAGNETIC-RESONANCE ; AMYLOID-BETA OLIGOMERS ; ALPHA-LACTALBUMIN ; IN-VITRO ; PEPTIDE AGGREGATION ; MISFOLDING DISEASES ; CARBONIC-ANHYDRASE ; ALZHEIMERS-DISEASE ; FOLDING PATHWAY |
| 资助项目 | National Natural Science Foundation of China[31170717] ; National Natural Science Foundation of China[91129713] ; National Natural Science Foundation of China[30900233] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4856347 |
| WOS记录号 | WOS:000319426800003 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277602]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Lin, Donghai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China 3.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 21009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Huang, Pei,Lian, Fulin,Wen, Yi,et al. Prion protein oligomer and its neurotoxicity[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(6):442-451. |
| APA | Huang, Pei,Lian, Fulin,Wen, Yi,Guo, Chenyun,&Lin, Donghai.(2013).Prion protein oligomer and its neurotoxicity.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(6),442-451. |
| MLA | Huang, Pei,et al."Prion protein oligomer and its neurotoxicity".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45.6(2013):442-451. |
入库方式： OAI收割
来源：上海药物研究所
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