Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion
文献类型：期刊论文
| 作者 | Yao, Zemin2; Zhou, Hu1 ; Figeys, Daniel2; Wang, Yuwei2; Sundaram, Meenakshi2
|
| 刊名 | CURRENT OPINION IN LIPIDOLOGY
 |
| 出版日期 | 2013-04 |
| 卷号 | 24期号:2页码:160-170 |
| 关键词 | apoC-III hypertriglyceridemia lipogenesis nonalcoholic fatty liver disease VLDL |
| ISSN号 | 0957-9672 |
| DOI | 10.1097/MOL.0b013e32835aebe7 |
| 文献子类 | Review |
| 英文摘要 | Purpose of review Liver is the major organ in mammals that possesses the capacity to release triglyceride within VLDL. VLDL assembly requires apolipoprotein (apo) B-100 with the assistance of microsomal triglyceride transfer protein (MTP), which facilitates the mobilization of triglyceride into the microsomal lumen. Recent experimental evidence has suggested that the lumenal triglyceride associated with endoplasmic reticulum (ER)/Golgi may represent an entity serving as precursors for large VLDL1. Recent findings Under lipid-rich conditions, discrete triglyceride-rich lipidic bodies, termed lumenal lipid droplets, are accumulated in association with ER/Golgi microsomes. Formation of the microsome-associated lumenal lipid droplets (MALD) is dependent on the activity of MTP, and the resulting apoB-free lipidic body is associated with a variety of proteins including apolipoproteins that are components of VLDL. Formation and utilization of MALD during the assembly and secretion of VLDL1 have a profound influence on hepatic cell physiology, such as ER stress responses. Summary This review summarizes current understanding of hepatic triglyceride homeostasis in general, and highlights the functional significance of triglyceride compartmentalization between cytosol and microsomes in particular. Understanding of MALD metabolism may shed new light on the prevention and treatment of liver diseases associated with abnormally elevated intracellular triglycerides. |
| WOS关键词 | TRIGLYCERIDE TRANSFER PROTEIN ; LOW-DENSITY LIPOPROTEINS ; CAUSES HEPATIC STEATOSIS ; LEPTIN-DEFICIENT MICE ; ENDOPLASMIC-RETICULUM ; LIVER-REGENERATION ; PPAR-GAMMA ; APOLIPOPROTEIN-B ; FATTY LIVER ; MOUSE-LIVER |
| 资助项目 | Canadian Institute of Health Research[00000000] ; Heart and Stroke Foundation of Canada[00000000] ; Canadian Research Chair of Proteomics and Systems Biology[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Cardiovascular System & Cardiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000316116100011 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277681]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Yao, Zemin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada; |
| 推荐引用方式 GB/T 7714 | Yao, Zemin,Zhou, Hu,Figeys, Daniel,et al. Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion[J]. CURRENT OPINION IN LIPIDOLOGY,2013,24(2):160-170. |
| APA | Yao, Zemin,Zhou, Hu,Figeys, Daniel,Wang, Yuwei,&Sundaram, Meenakshi.(2013).Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion.CURRENT OPINION IN LIPIDOLOGY,24(2),160-170. |
| MLA | Yao, Zemin,et al."Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion".CURRENT OPINION IN LIPIDOLOGY 24.2(2013):160-170. |
入库方式： OAI收割
来源：上海药物研究所
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