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Two new glycosidated coumaramides from Clerodendron cyrtophyllum

文献类型：期刊论文

作者Wang, Peng2; Sun, Li3; Tan, Junjie1; Xu, Jinwen3; Guo, Fujiang2; Li, Yiming2
刊名FITOTERAPIA
出版日期2012-12
卷号83期号:8页码:1494-1499
关键词Clerodendron cyrtophyllum Glycosidated coumaramides Inhibition of NF-kappa B
ISSN号0367-326X
DOI10.1016/j.fitote.2012.08.016
文献子类Article
英文摘要Two new glycosidated coumaramides clerodendiod A (1) and B (2), together with seven known glycosidic compounds were isolated from the branches of Clerodendron cyrrophyllum Turcz. Clerodendiod A and B were elucidated as beta-D-glucopyranosyl-(1 -> 3)-beta-D-glucopyranosyl-(1 -> 3)-[6-O-(E)-p-methoxycinnamoyl]-beta-D-glucopyranosyl-(1 -> 2)-[4-O-4((E)-2-(4-acetamidobutylcarbamoyl)vinyl)-phenyl]-alpha-L-rhamnopyranoside (1) and 6-O-(E)-p-coumaroyl-beta-D-glucopyranosyl-(1 -> 3)-beta-D-glucopyranosyl-(1 -> 3)-[6-O-(E)-p-methoxycinnamoyl]-beta-D-glucopyranosyl-(1 -> 2)-[4-O-((E)-2-(4-acetamidobutylcarbamoyl)vinyl)-phenyl]-alpha-L-rhamnopyranoside (2) on the basis of chemical and spectral evidence. The isolated new compound 2 was assayed for the inhibition of the NF-kappa B pathway and showed potent activity in inhibiting NF-kappa B which its IC50 values was found to be 24.9 nM. (C) 2012 Elsevier B.V. All rights reserved.
WOS关键词NF-KAPPA-B ; NECROSIS-FACTOR-ALPHA ; PHENOLIC ANTIOXIDANTS ; IRIDOID GLUCOSIDES ; CONSTITUENTS ; EXPRESSION ; INHIBITION ; INDUCTION ; SERRATUM ; PATHWAY
资助项目National Science and Technology Major Project of China[2009ZX09311-003] ; "Xing-lin" scholars and outstanding team training plan of SHUTCM[00000000]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000312916400029
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/277855]  
专题天然药物化学研究室
通讯作者Guo, Fujiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China;
3.Shanghai Univ Tradit Chinese Med, Murad Res Inst Modernized Chinese Med, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Wang, Peng,Sun, Li,Tan, Junjie,et al. Two new glycosidated coumaramides from Clerodendron cyrtophyllum[J]. FITOTERAPIA,2012,83(8):1494-1499.
APA Wang, Peng,Sun, Li,Tan, Junjie,Xu, Jinwen,Guo, Fujiang,&Li, Yiming.(2012).Two new glycosidated coumaramides from Clerodendron cyrtophyllum.FITOTERAPIA,83(8),1494-1499.
MLA Wang, Peng,et al."Two new glycosidated coumaramides from Clerodendron cyrtophyllum".FITOTERAPIA 83.8(2012):1494-1499.

入库方式： OAI收割

来源：上海药物研究所

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