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Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage

文献类型：期刊论文

作者Tian, Yu2; Ma, Chao2; Feng, Linyin1; Zhang, Lei1; Hao, Feiyue2; Pan, Li2; Cheng, Maosheng2
刊名ARCHIV DER PHARMAZIE
出版日期2012-06
卷号345期号:6页码:423-430
关键词Cerebral ischemia (-)-Linarinic acid derivatives Neuroprotective effect Oxygen glucose deprivation SH-SY5Y cells
ISSN号0365-6233
DOI10.1002/ardp.201100424
文献子类Article
英文摘要A series of novel (-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives were designed and synthesized. All of the prepared compounds were screened for their neuroprotective effects using an in vitro oxygen glucose deprivation (OGD) model of ischemic stroke. Some of the target compounds exhibited moderate to excellent protective potency. In particular, compounds 9d, 9e, 9g, and 9h showed significant protective effects in the SH-SY5Y cell line at all three concentrations tested.
WOS关键词OXYGEN-GLUCOSE DEPRIVATION ; CATALYZED REDUCTION ; HYDROGEN-PEROXIDE ; NITRO-COMPOUNDS ; HYDRAZINE ; APOPTOSIS ; ISCHEMIA ; CARBON ; MODEL
资助项目National Natural Science Foundation of China[30973613]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000305123700002
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/278056]  
专题药理学第二研究室
通讯作者Cheng, Maosheng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
2.Shenyang Pharmaceut Univ, Key Lab Struct Based Drugs Design & Discovery, Minist Educ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China;
推荐引用方式
GB/T 7714		 Tian, Yu,Ma, Chao,Feng, Linyin,et al. Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage[J]. ARCHIV DER PHARMAZIE,2012,345(6):423-430.
APA Tian, Yu.,Ma, Chao.,Feng, Linyin.,Zhang, Lei.,Hao, Feiyue.,...&Cheng, Maosheng.(2012).Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage.ARCHIV DER PHARMAZIE,345(6),423-430.
MLA Tian, Yu,et al."Synthesis and Biological Evaluation of (-)-Linarinic Acid Derivatives as Neuroprotective Agents against OGD-Induced Cell Damage".ARCHIV DER PHARMAZIE 345.6(2012):423-430.

入库方式： OAI收割

来源：上海药物研究所

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