NMR-based Metabolomic Analysis of Human Bladder Cancer
文献类型：期刊论文
| 作者 | Cao, Ming2; Zhao, Liangcai3; Chen, Haige2; Xue, Wei2; Lin, Donghai1,3 |
| 刊名 | ANALYTICAL SCIENCES
 |
| 出版日期 | 2012-05 |
| 卷号 | 28期号:5页码:451-456 |
| ISSN号 | 0910-6340 |
| DOI | 10.2116/analsci.28.451 |
| 文献子类 | Article |
| 英文摘要 | Bladder cancer (BC) is one of the most common cancers and has a high mortality rate. However, both metabolite variations and metabolic pathways related to the pathogenic process of BC remain to be addressed, such results might contribute to early detection of the disease. H-1 nuclear magnetic resonance (NMR)-based metabolomics was applied to identify differences of serum metabolic profiles among BC, calculi patients and healthy subjects. Serum metabolic profiles of BC patients are distinctly different from those of calculi and healthy subjects. Compared with those from healthy subjects, serum samples from BC patients show decreased levels of isoleucine/leucine, tyrosine, lactate, glycine, citrate, as well as increased levels of lipids and glucose. The results reveal disturbed metabolic pathways of aromatic amino acids, glycolysis and citrate cycle, as well as lipogenesis metabolism in BC patients. Our work will be of potential benefit to understanding the pathogenic process of BC and will offer valuable information for noninvasive diagnosis of the disease. |
| WOS关键词 | CELL CARCINOMA ; PLASMA ; TYROSINE ; STROMA ; SERUM ; H-1 ; PHENYLALANINE ; SPECTROSCOPY ; SPECTROMETRY ; METABONOMICS |
| 资助项目 | National Natural Science Foundation of China[81100598] ; National Natural Science Foundation of China[91129713] ; National Natural Science Foundation of China[31170717] ; Program of Shanghai Subject Chief Scientist[09XD1405100] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000304724000004 |
| 出版者 | JAPAN SOC ANALYTICAL CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278085]  |
| 专题 | 分析化学研究室 |
| 通讯作者 | Xue, Wei |
| 作者单位 | 1.Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol Surg, Shanghai 200001, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cao, Ming,Zhao, Liangcai,Chen, Haige,et al. NMR-based Metabolomic Analysis of Human Bladder Cancer[J]. ANALYTICAL SCIENCES,2012,28(5):451-456. |
| APA | Cao, Ming,Zhao, Liangcai,Chen, Haige,Xue, Wei,&Lin, Donghai.(2012).NMR-based Metabolomic Analysis of Human Bladder Cancer.ANALYTICAL SCIENCES,28(5),451-456. |
| MLA | Cao, Ming,et al."NMR-based Metabolomic Analysis of Human Bladder Cancer".ANALYTICAL SCIENCES 28.5(2012):451-456. |
入库方式： OAI收割
来源：上海药物研究所
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