17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages
文献类型：期刊论文
| 作者 | Uto, Takuhiro2; Qin, Guo-Wei1; Morinaga, Osamu2; Shoyama, Yukihiro2 |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2012-01 |
| 卷号 | 12期号:1页码:101-109 |
| 关键词 | Jolkinolide Prostaglandin E2 Nitric oxide Cytokines Heme oxygenase-1 Macrophages |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2011.10.020 |
| 文献子类 | Article |
| 英文摘要 | Jolkinolides are the main abietane-type diterpenoids isolated from the root of Euphorbia fischeriana Steud. In the present study, we investigated in vitro anti-inflammatory activity of four structural analogs of jolkinolide in lipopolysaccharide (LPS)-stimulated RAW264 macrophages. Among these jolkinolides, 17-hydroxy-jolkinolide B (HJB) exhibited the most potent inhibition of LPS-induced production of inflammatory mediators such as prostaglandin E-2 (PGE(2)), nitric oxide (NO), and pro-inflammatory cytokines linterleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha)]. HJB could decrease LPS-induced protein levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the mRNA expressions of COX-2, iNOS, IL-6, and TNF-alpha in a concentration-dependent manner. These inhibitory effects were caused by suppression of MAPK phosphorylation and NF-kappa B activation. Furthermore, we demonstrated that HJB strongly induced heme oxygenase-1 (HO-1) protein and mRNA expressions. These findings suggest that HJB possesses anti-inflammatory actions in macrophages and may provide a potential therapeutic approach for inflammatory disorders. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS关键词 | NF-KAPPA-B ; INDUCIBLE NITRIC-OXIDE ; CARBON-MONOXIDE ; ANTIINFLAMMATORY DRUGS ; SYNTHASE EXPRESSION ; SIGNAL-TRANSDUCTION ; INTERFERON-GAMMA ; GENE-EXPRESSION ; JOLKINOLIDE-B ; JNK PATHWAY |
| 资助项目 | Japan Society for the Promotion of Science (JSPS)[00000000] ; Japan Science and Technology Agency (JST)[00000000] ; Japan International Cooperation Agency (JICA)[00000000] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000300969200014 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278270]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Shoyama, Yukihiro |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai 201203, Peoples R China 2.Nagasaki Int Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Sasebo, Nagasaki 8593298, Japan; |
| 推荐引用方式 GB/T 7714 | Uto, Takuhiro,Qin, Guo-Wei,Morinaga, Osamu,et al. 17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2012,12(1):101-109. |
| APA | Uto, Takuhiro,Qin, Guo-Wei,Morinaga, Osamu,&Shoyama, Yukihiro.(2012).17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages.INTERNATIONAL IMMUNOPHARMACOLOGY,12(1),101-109. |
| MLA | Uto, Takuhiro,et al."17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages".INTERNATIONAL IMMUNOPHARMACOLOGY 12.1(2012):101-109. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。