Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
文献类型：期刊论文
| 作者 | Zhao, Gang1,2; Chen Yao-Yue2; Qin, Guo-Wei3; Guo, Li-He1,2 |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2012-01 |
| 卷号 | 33期号:1页码:176-186 |
| 关键词 | Antioxidation Hydrogen peroxide Luteolin Neuroprotectant Oxidant-antioxidant balance Reactive oxygen species |
| ISSN号 | 0197-4580 |
| DOI | 10.1016/j.neurobiolaging.2010.02.013 |
| 文献子类 | Article |
| 英文摘要 | Increased attention has been paid to the role of oxidant/antioxidant imbalance in neurodegenerative process and pharmaceutical neuroprotective interventions. Food-derived compound luteolin possesses multitarget actions including reactive oxygen species (ROS)-scavenging activity in cultured human endothelial cells or permanent immature rat oligodendrocytes. This study aims to elucidate whether luteolin has a neuroprotective tendency toward ROS-insulted neural cells. The present results showed that luteolin, isolated from the ripe seed of Perilla frutescens (L.) Britt., markedly reversed hydrogen peroxide-induced cytotoxicity in primary culture cortical neurons but not in cultured human neuroblastoma cells. Upon the ROS-insulted primary neurons, luteolin concentration-dependently enhanced neuronal cell survival with efficacy higher than and potency similar to vitamin E. Additionally, luteolin significantly attenuated the increase in ROS production and prevented the decreases in activities of mitochondria, catalase, and glutathione in ROS-insulted primary neurons. Thus, luteolin functions by neuroprotection possibly through a rebalancing of pro-oxidant-antioxidant status. This agent points to possible interventions for preventing neurodegenerative diseases such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease, as well as for improving brain aging. (C) 2012 Elsevier Inc. All rights reserved. |
| WOS关键词 | OXIDATIVE STRESS ; ROSMARINIC ACID ; FREE-RADICALS ; CORTICAL-NEURONS ; CELLS ; APOPTOSIS ; ANTIOXIDANTS ; EXTRACT ; NEURODEGENERATION ; DISEASE |
| 资助项目 | Shanghai Government[05DZ19339] ; Chinese Academy of Science[00000000] |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000297934700016 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278290]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Guo, Li-He |
| 作者单位 | 1.Cell Star Biotechnol Co Ltd, Shanghai, Peoples R China; 2.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Gang,Chen Yao-Yue,Qin, Guo-Wei,et al. Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons[J]. NEUROBIOLOGY OF AGING,2012,33(1):176-186. |
| APA | Zhao, Gang,Chen Yao-Yue,Qin, Guo-Wei,&Guo, Li-He.(2012).Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons.NEUROBIOLOGY OF AGING,33(1),176-186. |
| MLA | Zhao, Gang,et al."Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons".NEUROBIOLOGY OF AGING 33.1(2012):176-186. |
入库方式： OAI收割
来源：上海药物研究所
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