Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1
文献类型：期刊论文
| 作者 | Mueller, Werner E. G.5; Binder, Michael5; von Lintig, Johannes1; Guo, Yue-Wei2 ; Wang, Xiaohong3,5; Kaandorp, Jaap A.4; Wiens, Matthias5; Schroeder, Heinz C.5
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| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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| 出版日期 | 2011-12 |
| 卷号 | 1810期号:12页码:1178-1194 |
| 关键词 | Retinoic acid BMP-1 beta-Carotene dioxygenase Retinal dehydrogenase Silicatein Silintaphin-2 |
| ISSN号 | 0304-4165 |
| DOI | 10.1016/j.bbagen.2011.09.006 |
| 文献子类 | Article |
| 英文摘要 | Background: The formation of the spicules in siliceous sponges involves the formation of cylinder-like structures in the extraspicular space, composed of the enzyme silicatein and the calcium-dependent lectin. Scope of review: Molecular cloning of the cDNAs (carotene dioxygenase, retinal dehydrogenase, and BMB-1 [bone morphogenic protein-1]) from the demosponge Suberites domuncula was performed. These tools were used to understand the retinoid metabolism in the animal by gRT-PCR, immunoblotting and TEM. Major conclusions: We demonstrate that silintaphin-2, a silicatein-interacting protein, is processed from a longer-sized 15-kDa precursor to a truncated, shorter-sized 13 kDa calcium-binding protein via proteolytic cleavage at the dipeptide Ala down arrow Asp, mediated by BMP-1. The expression of this protease as well as the expression of two key enzymes of the carotinoid metabolism, the beta beta-carotene-15,15'-dioxygenase and the retinal dehydrogenase/reductase, were found to be strongly up-regulated by retinoic acid. Hence retinoic acid turned out to be a key factor in skeletogenesis in the most ancient still existing metazoans, the sponges. General significance: It is shown that retinoic acid regulates the formation of the organic cylinder that surrounds the axis of the spicules and enables, as a scaffold, the radial apposition of new silica layers and hence the growth of the spicules. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS关键词 | SHORT-CHAIN DEHYDROGENASE/REDUCTASE ; PROCOLLAGEN C-PROTEINASE ; MINIMAL DOMAIN-STRUCTURE ; GEODIA-CYDONIUM LECTIN ; VITAMIN-A PRODUCTION ; FRESH-WATER SPONGES ; BETA-CAROTENE ; IN-VITRO ; SILICEOUS SPICULES ; BINDING-PROTEINS |
| 资助项目 | ERC[268476 - BIOSILICA] ; German Bundesministerium fur Bildung und Forschung[00000000] ; Deutsche Forschungsgemeinschaft[Schr 277/10-1] ; European Commission/EUREKA (EUROSTARS)[4289 - SILIBACTS] ; International Human Frontier Science Program[00000000] ; European Commission[244967 - Mem-S] ; Ministry of Land and Resources of the People's Republic of China[201011005-06] ; International S & T Cooperation Program of China[2008DFA00980] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000297885300007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278316]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Mueller, Werner E. G. |
| 作者单位 | 1.Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44160 USA; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Natl Res Ctr Geoanal, Beijing 100037, Peoples R China; 4.Univ Amsterdam, Sect Computat Sci, NL-1098 SJ Amsterdam, Netherlands 5.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, ERC Adv Grant Res Grp, D-55128 Mainz, Germany; |
| 推荐引用方式 GB/T 7714 | Mueller, Werner E. G.,Binder, Michael,von Lintig, Johannes,et al. Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2011,1810(12):1178-1194. |
| APA | Mueller, Werner E. G..,Binder, Michael.,von Lintig, Johannes.,Guo, Yue-Wei.,Wang, Xiaohong.,...&Schroeder, Heinz C..(2011).Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1810(12),1178-1194. |
| MLA | Mueller, Werner E. G.,et al."Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1810.12(2011):1178-1194. |
入库方式： OAI收割
来源：上海药物研究所
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