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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
文献类型：期刊论文
| 作者 | Tan, Minjia1 ; Luo, Hao1; Lee, Sangkyu1; Jin, Fulai4,5; Yang, Jeong Soo1; Montellier, Emilie2,3,8; Buchou, Thierry2,3,8; Cheng, Zhongyi1; Rousseaux, Sophie2,3,8; Rajagopal, Nisha4,5
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| 刊名 | CELL
 |
| 出版日期 | 2011-09-16 |
| 卷号 | 146期号:6页码:1015-1027 |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2011.08.008 |
| 文献子类 | Article |
| 英文摘要 | We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic localization of histone Kcr suggest that it is mechanistically and functionally different from histone lysine acetylation (Kac). Specifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active promoters or potential enhancers. In male germinal cells immediately following meiosis, Kcr is enriched on sex chromosomes and specifically marks testis-specific genes, including a significant proportion of X-linked genes that escape sex chromosome inactivation in haploid cells. These results therefore dramatically extend the repertoire of histone PTM sites and designate Kcr as a specific mark of active sex chromosome-linked genes in postmeiotic male germ cells. |
| WOS关键词 | MASS-SPECTROMETRY ; POSTTRANSLATIONAL MODIFICATIONS ; CHROMATIN MODIFICATIONS ; HUMAN-CELLS ; CODE ; DISTINCT ; H3 ; PHOSPHORYLATION ; ACETYLATION ; METHYLATION |
| 资助项目 | National Institute of Health[00000000] ; INCa-DHOS[00000000] ; ANR blanche "EpiSperm"[00000000] ; ARC[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000295258100022 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278400]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Zhao, Yingming |
| 作者单位 | 1.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA; 2.Univ Grenoble 1, F-38706 La Tronche, France; 3.Fac Med, Inst Albert Bonniot, F-38706 La Tronche, France 4.Univ Calif San Diego, Ludwig Inst Canc Res, Sch Med, La Jolla, CA 92093 USA; 5.Univ Calif San Diego, Dept Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 7.Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA; 8.INSERM, U823, F-38706 La Tronche, France; |
| 推荐引用方式 GB/T 7714 | Tan, Minjia,Luo, Hao,Lee, Sangkyu,et al. Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification[J]. CELL,2011,146(6):1015-1027. |
| APA | Tan, Minjia.,Luo, Hao.,Lee, Sangkyu.,Jin, Fulai.,Yang, Jeong Soo.,...&Zhao, Yingming.(2011).Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification.CELL,146(6),1015-1027. |
| MLA | Tan, Minjia,et al."Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification".CELL 146.6(2011):1015-1027. |
入库方式： OAI收割
来源：上海药物研究所
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