PURINIUM DERIVATIVES WITH ANTITUMOR ACTIVITIES FROM HETEROSTEMMA ALATUM WIGHT
文献类型：期刊论文
| 作者 | Fu, Wen-Wei1,2,6; Tan, Chang-Heng6 ; Zhuang, Peng-Yu3; Yang, Shu-Min6; Luo, Hong-Feng6; Tan, Jun-Jie6; Liu, Ping1,2,4,5; Zhu, Da-Yuan6
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| 刊名 | HETEROCYCLES
 |
| 出版日期 | 2011-06-01 |
| 卷号 | 83期号:6页码:1405-1408 |
| 关键词 | Heterostemma alatum Wight Heteromine I Heteromine D Cytotoxicity |
| ISSN号 | 0385-5414 |
| DOI | 10.3987/COM-11-12204 |
| 文献子类 | Article |
| 英文摘要 | Heteromine 1 (1), a new purinium derivative, together with six known compounds, were isolated from the aerial parts of Heterostemma alatum Wight. The structure of 1 has been established as 2-methylamino-6-methoxy-7,9-dimethyl-8-purinone by means of spectroscopic analysis. Two puriniums, heteromines J (2) and K (3) were isolated as natural products for the first time. Heteromine D (4) showed strong cytotoxicity against HL-60 cell line with IC(50) of 4.04 nmol/mL. |
| WOS关键词 | HETEROMINE ; BROWNII |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09311-003] ; National Science Foundation of China[81072545] ; China Postdoctoral Science Foundation[20090460644] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000292671600017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278510]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Fu, Wen-Wei |
| 作者单位 | 1.Shanghai Shuguang Hosp, Inst Liver Dis, Shanghai 201203, Peoples R China; 2.Shanghai Shuguang Hosp, Shanghai Clin Key Lab Tradit Chinese Med, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, Shanghai Univ, E Inst Tradit Chinese Med Internal Med, Shanghai 201203, Peoples R China; 5.Shanghai Univ Tradit Chinese Med, Key Lab Liver & Kidney Dis, Shanghai 201203, Peoples R China 6.CAS, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fu, Wen-Wei,Tan, Chang-Heng,Zhuang, Peng-Yu,et al. PURINIUM DERIVATIVES WITH ANTITUMOR ACTIVITIES FROM HETEROSTEMMA ALATUM WIGHT[J]. HETEROCYCLES,2011,83(6):1405-1408. |
| APA | Fu, Wen-Wei.,Tan, Chang-Heng.,Zhuang, Peng-Yu.,Yang, Shu-Min.,Luo, Hong-Feng.,...&Zhu, Da-Yuan.(2011).PURINIUM DERIVATIVES WITH ANTITUMOR ACTIVITIES FROM HETEROSTEMMA ALATUM WIGHT.HETEROCYCLES,83(6),1405-1408. |
| MLA | Fu, Wen-Wei,et al."PURINIUM DERIVATIVES WITH ANTITUMOR ACTIVITIES FROM HETEROSTEMMA ALATUM WIGHT".HETEROCYCLES 83.6(2011):1405-1408. |
入库方式： OAI收割
来源：上海药物研究所
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